<p>没人顶 是因為书不曉得給誰看啊</p><p>【书名】 ADVANCES IN CLINICAL TRIAL BIOSTATISTICS<br/>【作者】NANCY L. GELLER<br/>【出版社】 by Marcel Dekker,<br/>【版本】1<br/>【出版日期】2004<br/>【文件格式】PDF<br/>【文件大小】2.14 Mb<br/>【页数】 278 including cover <br/>【ISBN出版号】ISBN: 0-8247-9032-4<br/>【资料类别】统计学,textbook<br/>【市面定价】89.1 USD<br/>【扫描版还是影印版】original<br/>【是否缺页】complete<br/>【关键词】biostatistics, clinical trial <br/>【内容简介】From aspects of early trials to complex modeling problems, Advances in Clinical Trial Biostatistics summarizes current methodologies used in the design and analysis of clinical trials. Its chapters, contributed by internationally renowned methodologists experienced in clinical trials, address topics that include Bayesian methods for phase I clinical trials, adaptive two-stage clinical trials, and the design and analysis of cluster randomization trials, trials with multiple endpoints, and therapeutic equivalence trials. Other discussions explore Bayesian reporting, methods incorporating compliance in treatment evaluation, and statistical issues emerging from clinical trials in HIV infection. </p><p>【目录】<br/>Contents<br/>Series Introduction<br/>Preface<br/>Contributors<br/>Part I METHODS FOR EARLY TRIALS<br/>1. Bayesian Methods for Cancer Phase I Clinical Trials<br/>2. Design of Early Trials in Stem Cell Transplantation:<br/>A Hybrid Frequentist-Bayesian Approach</p><p>Part II METHODS FOR RANDOMIZED TRIALS<br/>3. Design and Analysis of Therapeutic Equivalence Trials<br/>4. Adaptive Two-Stage Clinical Trials<br/>5. Design and Analysis of Cluster Randomization Trials<br/>6. Design and Analysis of Clinical Trials with Multiple<br/>Endpoints<br/>7. Subgroups and Interactions<br/>8. A Class of Permutation Tests for Some Two-Sample<br/>Survival Data Problems<br/>9. Bayesian Reporting of Clinical Trials</p><p>Part III MORE COMPLEX PROBLEMS<br/>10. Methods Incorporating Compliance in Treatment<br/>Evaluation<br/>11. Analysis of Longitudinal Data with Missingness<br/>12. Statistical Issues Emerging from Clinical Trials in HIV<br/>Infection</p><p>Index of Abbreviations<br/>Index of Clinical Trials Used as Examples<br/>Subject Index</p><p>【原创书评】Clinical trial 與實驗室bench實驗不同之處在於試驗的對象是人,而人都會希望自己得到最好的治療. 因此又發展出許多不同的實驗設計方法,特別是在符合Declaration of Helsinki的普世價值之下. 這本書討論的內容相對來說比較屬於介紹統計建模的工具,前面先用例題作出dose-response curve. 後面是對一些特定情況介紹一些檢定工具. 這本書比較屬review 性質並沒有很多公式推導的來源, 有作過一些這類分析的朋友可能比較能領會; 不熟悉這塊的人可能會望書興嘆(沒有sas or R code).</p>
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