发布时间：2015-04-01 来源：人大经济论坛

制药工程论文范文 目 录 中文摘要..........................................................I 英文摘要..........................................................II 目录..............................................................III 1. 绪论...........................................................1 1.1 引言......................................................1 1.2 研究现状..................................................1 1.3 立题依据..................................................5 2. 实验部分.......................................................6 2.1 实验仪器与试剂............................................6 2.2 实验的制备过程............................................7 2.3 载药量的测定..............................................9 2.4 纳米粒粒径的测定..........................................12 3. 偶联物CHS-F的检测..............................................13 3.1 紫外扫描..................................................13 3.2 傅立叶红外分析............................................15 3.3 差示量扫描热DSC...........................................17 3.4 高效分离..................................................18 4. 结果与讨论.....................................................19 4.1 氟伐他汀钠合成过程分析....................................19 4.2 偶联物的制备过程分析......................................20 4.3 CHS-F彻底水解的酸碱比较...................................21 4.4 纳米粒的高效分离测定分析..................................21 4.5 载药量的比较..............................................22 4.6 实验小结..................................................22 5. 总结与展望.....................................................23 5.1 实验总结..................................................23 5.2 展望......................................................23 致谢..............................................................24 参考文献..........................................................25 摘 要：氟伐他汀酯经氢氧化钠（1N）水解制备得到降血脂药物氟伐他汀钠。为对其进行剂型改造研究，我们采用两种方法制备壳聚糖-氟伐他汀的偶联物和纳米粒。偶联物通过UV、IR、DSC进行结构确认，得到以酰胺键相联的壳聚糖-氟伐他汀偶联物；纳米粒通过激光粒度纳米仪进行粒径测定。两种制备方法制备得到的壳聚糖-氟伐他汀通过高效液相来测定其含量，并计算出载药量，纳米粒的载药量达到43.67%，偶联物的载药量达到25.03%。 关键词：壳聚糖；氟伐他汀；偶联物；纳米粒 Abstract: Fluvastatin sodium，a hypolipidemic drug，was prepared by ester hydrolysis from fluvastatin ester with 1N sodium hydroxide. In order to enrich the dosage forms of chitosan-fluvastatin combination, we choosed two kind of methods to to prepare fluvastatin-chitosan conjugate and nanoparticles. Fluvastatin was chemically coupled to chitosan to form chitosan-fluvastatin conjugate, which was confirmed by UV、IR、DSC. The size of nanoparticles was determined by laser scattering instrument. The concentration of the two kinds of chitosan- fluvastatin were determined by HPLC, then calculated the drug-loading rate. After experiment, the drug-loading rate of nanoparticles was 43.67%, and conjugate was 25.03%. Keywords：Chitosan; Fluvastatin; conjugate; nanoparticle