Biostatistics-A Methodology for the Health Sciences
Second Edition
GERALD VAN BELLE
LLOYD D. FISHER
PATRICK J. HEAGERTY
THOMAS LUMLEY


Contents
Preface to the First Edition ix
Preface to the Second Edition xi
1. Introduction to Biostatistics 1
2. Biostatistical Design of Medical Studies 10
3. Descriptive Statistics 25
4. Statistical Inference: Populations and Samples 61
5. One- and Two-Sample Inference 117
6. Counting Data 151
7. Categorical Data: Contingency Tables 208
8. Nonparametric, Distribution-Free, and Permutation Models:
Robust Procedures 253
9. Association and Prediction: Linear Models with One
Predictor Variable 291
10. Analysis of Variance 357
11. Association and Prediction: Multiple Regression Analysis
and Linear Models with Multiple Predictor Variables 428
12. Multiple Comparisons 520
13. Discrimination and Classification 550
14. Principal Component Analysis and Factor Analysis 584
vii
viii CONTENTS
15. Rates and Proportions 640
16. Analysis of the Time to an Event: Survival Analysis 661
17. Sample Sizes for Observational Studies 709
18. Longitudinal Data Analysis 728
19. Randomized Clinical Trials 766
20. Personal Postscript 787