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含二催化中心手性配体的鉴定_制药工程论文范文
制药工程论文范文 目 录 中文摘要I 英文摘要II 目录III 1. 绪论1 1.1 手性化合物在医药领域的应用1 1.2 手性氨基醇的合成2 1.3 手性氨基醇在不对称催化中的应用4 1.4 外消旋化合物的拆分5 1.5 展望6 2. 实验部分7 2.1 实验仪器7 2.2 实验试剂和原料7 2.3 熔点的测定8 2.4 旋光度的测定8 2.5 本章小结8 2.6 流程图9 3. 结果与讨论10 3.1实验结果10 3.2实验讨论12 4．总结与展望14 致谢15 参考文献16 摘要：手性氨基醇在不对称合成领域中是一类重要的手性源，同时,手性氨基醇在药物合成和外消旋体拆分等领域也具有广泛的用途。本论文在查阅相关资料的基础上验证了不对称催化还原反应的研究新进展。 为寻找性能优异的催化剂，基于多催化中心配体在不对称还原反应中的协同效应，可获得手性仲醇较高的e.e.值。我们分别使用了（1R,2S）-（-）或（1S,2R）-（+）-2-氨基-1，2-二苯基乙醇为手性源与间二苄溴反应，经优化反应条件后在乙腈溶液中，于60-65℃下，以KI为催化剂，K2CO3为缚酸剂,合成了二催化中心配体：N-(1’R，2’S)-（1’,2’-二苯基-2’-羟基）和N-(1’S，2’R)-（1’，2’-二苯基-2’-羟基）乙基-间二苄胺，经硅胶柱色谱纯化得无色晶体，产率较高。产物结构经IR、MS、1HNMR等确认，在新合成的一对对映体中，其光谱性质、比旋光度等物理常数均得到很好的验证。 关键词：手性氨基醇；配体；鉴定 Abstract: Chiral amino alcohol in the field of asymmetric synthesis is a kind of important chiral source, at the same time,chiral amino alcohol has extensively applicates in drug synthesis and separation raceme with broad areas . In this paper，the inspection on the based of the relevent summarizes the asymmetric catalytic reduction of new progress. In order to find the catalytic performance,based on more catalysis center ligand in asymmetric caltalytic reduction of synergies，can achieve available chiral seconddary alcohols higher e.e. value. We were respectively using (1R, 2S )-(-) and (1S, 2R )-(+)- 2 - amino -1,2 – diphenyl ethanol as chiral sources with 1，3-benzyl bromide reponse by optimizing the reaction conditions in acetonitrile solution，in the 60-65℃，KI as a catalyst，K2CO3as a hydrogen absorption reagent first synthesized the catalysis center with the ligand： N-(1'R, 2'S) - (1 ', 2'- diphenyl -2 '- hydroxy) and N-(1'S, 2'R) - (1', 2'-diphenyl -2 '- hydroxy) ethyl -1’,3’- benzyl amine,by silica gel column chromatograp get the colorless crystal, yields are higher . Product by the IR、MS and 1HNMR，ect. Confirmed. Pairs enantiomer in the synthesis，their action spectrum character，the melting point and specific rotation etc. Other physcal constants are very good test.Keywords: Chiral Amino Alcohols; Ligand; Identification
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含双催化中心手性氨基醇配体的合成及纯化_制药工程论文
制药工程论文范文 目 录 中文摘要I 英文摘要II 目录III 1. 绪论1 1.1 研究手性药物的意义2 1.2 手性氨基醇及其应用3 1.3 手性氨基醇的合成4 1.4 手性氨基醇的发展前景5 2. 实验部分6 2.1 实验仪器6 2.2 实验试剂6 2.3 合成路线设计6 2.4 实验步骤7 2.4.3 色谱层析纯化8 2.5 本章小结8 2.6 流程图9 3. 结果与讨论10 3.1 实验结果10 3.2 实验讨论12 4．总结14 致谢15 参考文献16 摘 要：手性仲醇是天然产物及手性药物的重要合成砌块，也是合成具有手性功能材料的重要中间体，获得手性仲醇高对映体过量百分率（e.e.值）的重要方法之一是由手性氨基醇配体还原前手性酮获得。手性仲醇成为近年来最为活跃的研究领域之一。本论文在查阅相关资料的基础上综述了不对称催化还原反应研究新进展。 为了寻找性能优异的催化剂，基于多催化中心配体在不对称还原反应的协同效应，可获得手性仲醇较高的e.e.值。我们分别使用了(1S,2R)-(+)或(1R,2S)-(-)-2-氨基-1,2-二苯基乙醇为手性源与间二苄溴反应，经优化反应条件后在乙腈溶液中，于65℃下，以KI为催化剂，K2CO3为吸氢剂首次合成了含双催化中心配体，N-(1＇R,2＇S)-(1＇,2＇-二苯基-2＇-羟基) 乙基-间二苄胺和N-(1＇S,2＇R)-(1＇,2＇-二苯基-2＇-羟基)乙基-间二苄胺，经过硅胶柱色谱纯化得无色晶体，获得较好的产率。 关键词：手性氨基醇；配体；合成；纯化 Abstract: Chiral alcohols is a natural product and the importance intermediate of chiral drugs synthesis as well as chiral synthesis of functional materials. One of the important ways to acquire chiral secondary alcohols high enantiomeric excess percentage(e.e.value) is by chiral amino alcohols ligand catalytic reduction of prochiral ketone access. Chiral alcohol has become one of the most active research areas in recent years. In this paper, the inspection on the basis of relevant information summarizes the asymmetric catalytic reduction reaction of new progress. In order to find high performance catalyst remains, based on more catalysis center ligand in asymmetric catalytic reduction of synergies, can achieve available chiral secondary alcohols higher e.e.value. We were respectively using (1S,2R)-(+) and (1R,2S)-(-)-2-amino-1,2-diphenyl ethanol as chiral sources with 1,3-benzyl bromide reponse by optimizing the reaction conditions in acetonitrile solution, in 65℃, KI as a catalyst and K2CO3 as a hydrogen absorption reagent first synthesized the catalysis center with two ligand, N-(1＇R,2＇S)-(1＇,2-diphenyl-2＇-hydroxyl) ethyl-1,3-benzyl amine and N-(1＇S,2＇R)-(1＇,2-diphenyl-2＇-hydroxyl) ethyl-1,3-benzyl amine, by silica gel column chromatography get the colorless crystal. It has good yield. Keywords：Chiral Amino Alcohols;Ligand ; Synthesize ; Purify
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阿斯匹林-壳聚糖偶联物的合成_制药工程论文范文
制药工程论文范文 目 录 中文摘要…………………………………………………………………………………………I 英文摘要 ………………………………………………………………………………………II 目录 …………………………………………………………………………………………III 1．绪论 …………………………………………………………………………………………1 1.1 引言……………………………………………………………………………………1 1.2阿司匹林概况 ……………………………………………………………………1 1.3 甲壳素概况……………………………………………………………………… 2 1.4立题依据……………………………………………………………………………6 2.实验部分 …………………………………………………………………………………8 2.1 实验仪器与试剂 …………………………………………………………………8 2.2 壳聚糖-阿司匹林偶联物的合成………………………………………………… 9 2.3偶联物的水解实验 ………………………………………………………………10 2.4紫外光谱扫描 ……………………………………………………………………10 2.5傅立叶转换红外线光谱表征………………………………………………………12 2.6 差示扫描量法（DSC） ……………………………………………………………12 2.7液相色谱分析……………………………………………………………………… 13 2.8初步稳定性研究…………………………………………………………………… 13 3. 结果与讨论 …………………………………………………………………………… 15 3.1 水解实验 …………………………………………………………………………… 17 3.2偶联物结构表征……………………………………………………………………… 17 3.3载药量分析………………………………………………………………………… 18 3.4初步稳定性研究………………………………………………………………………19 4. 总结与展望 ………………………………………………………………………………20 致谢 ……………………………………………………………………………………………21 参考文献 ………………………………………………………………………………………2 摘要： 为了改善阿司匹林药效，降低其毒副作用，研制出一种副作用低的缓释药物壳聚糖－阿司匹林偶联物。本文采用1-(3-二甲氨基丙基)-3-乙基碳二亚胺（EDC）和N-羟基琥珀酰亚胺（NHS）作为缩合剂，在室温常压下，合成阿司匹林－壳聚糖共价偶联物。该偶联物经过红外（IR）、紫外（UV）、差示扫描量热（DSC）分析，结构得到确证，经高效液相色谱测定偶联物的载药量为30.93%，阿司匹林转化率为21.70%。对制备的阿司匹林－壳聚糖共价偶联物进行初步吸湿性、pH稳定性的考察，偶联物在湿度在64.０%以上，吸湿明显；pH6.0~pH7.0之间相对稳定。 关键词：阿司匹林，壳聚糖，偶联 Abstract Objective: To improve the drug effect of aspirin, reduce its side effect, we sucessfully synthesize chitosan-aspirin conjugate with lower side effect．In this paper chitosan-aspirin was synthesized via EDC and NHS in normal pressure and room temperature. The product was characterized by FT-IR、UV and DSC. The drug-loading rate of product reached upto30.93% measured by HPLC and the conversion rate of aspirin reached upto 21.70%. Then we pilot studied the hygroscopicity and pH stability of the conjugate. The research results showed the humidity of the conjugate obvious increased in more than 64.0 percent moisture; the conjugate relatively was stable between.pH6.0 ~ pH7.0. Key Words:Chitosan;Aspirin ; Coupling inspect
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微波对木薯淀粉可食膜性能的影响_制药工程论文范文
制药工程论文范文 目 录 中文摘要I 英文摘要II 目录III 1. 绪论1 1.1 可食性膜的发展现状1 1.2 可食性膜的特点1 1.3 可食性膜包装的应用2 1.4 可食性膜的种类3 1.5 可食性膜的前景预测5 1.6 本课题的主要研究内容6 1.7 本章小结6 2. 实验部分7 2.1 实验原料与试剂7 2.2 实验设备和仪器7 2.3 实验方法7 2.4 本章小结11 3. 结果与讨论12 3.1 膜性能数据的分析12 3.2 膜最佳配方及最适实验条件12 3.3 本可食膜的优缺点12 3.4 本可食膜的应用性12 3.5 本章小结12 4. 总结与展望 13 致谢15 参考文献16 摘 要：作为新型的食品包装，具有多种良好特性，且种类多样，可根据不同的食品特性进行选择，具有较高的应用价值和较大的应用范围。本论文通过对增稠剂CMC、木薯淀粉的性质和功能等的分析、进行实验。通过对比实验研究不同用量，不同条件下对成膜特性的影响,具体通过对可食膜的感官评定、力学分析、功能性等方面研究膜的性能，筛选得到成膜性能最佳时CMC、木薯淀粉的最适用量，以及膜成分中的增塑剂甘油的用量。结果表明：CMC6mL，木薯淀粉2.0g，甘油2.4mL，糊化温度为71℃，干燥温度50℃，干燥时间30min,可制得性能较好的膜。为了提高木薯淀粉可食膜的性能，通过微波进行处理，考察微波对可食膜性能的影响。结果表明：由于微波处理作用，可食膜机械性能增加显著，阻水性能也得到提高。 关键词：CMC；可食性膜；微波 Abstract：As a new type of food packaging, it has a variety of good characteristics, and the types of diversity, according to different properties of food, and have a high value and greater scope of application. Thickening of this thesis through the CMC, tapioca starch, such as the nature and function analysis of the experiment. By orthogonal experimental study of different dosage, under different conditions of film-forming characteristics of the specific through the sensory eva luation of edible coating, mechanical analysis, functional areas such as studying the performance of the films, screening has been the best when the film-forming properties of CMC, The optimum amount of cassava starch, as well as the membrane component of the amount of glycerin. The results showed that: It can be obtained better performance of the film when CMC6mL, cassava starch 0.2g, glycero2.4mL, pasting temperature 71℃ drying temperature 50℃ for 30min, can be obtained a better membrane performance. In order to improve cassava starch edible film properties by microwave processing, microwave study of the properties of edible films. The results showed that:because of the role of microwave treatment, the mechanical properties of edible films to increase significantly, water blocking performance is improved. Keywords：CMC; edible film; microwave
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洋葱油的GCMS分析_制药工程论文范文
制药工程论文范文 目 录 中文摘要I 英文摘要II 目录III 1. 绪论1 1.1 洋葱的生态习性1 1.2 洋葱的营养成分1 1.3 洋葱的保健功效2 1.4 洋葱油制备方法3 1.5 超临界萃取原理3 1.6 气相色谱-质谱联用5 1.6.1 气相色谱5 1.6.2 质谱6 1.6.3 气相色谱-质谱联用6 2. 实验部分7 2.1 材料与方法7 2.1.1 材料和仪器7 2.2 洋葱挥发油的提取7 2.3 洋葱挥发油的分析8 2.3.1 气相分析8 2.3.2 气相色谱-质谱联用分析9 3. 结果与讨论9 3.1 洋葱油的产率9 3.2 洋葱油的GC-MS分析10 3.3 结论12 4. 总结与展望12 致谢13 参考文献14 附录16 摘 要：本论文主要讨论的洋葱中的活性物质（洋葱油）及其中各个组分相对含量。考虑到洋葱油在新鲜洋葱中的含量极少，故采用脱水洋葱粉替代，同时洋葱油中部分为热敏性物质，为了使其不在萃取过程被破坏分解，决定采用超临界二氧化碳萃取装置制备洋葱油。通过气相色谱-质谱联用技术对洋葱油中化学成分进行了分析，分离出65个色谱峰，鉴定出19个物质，其中有几个是首次从洋葱中分离得到的。已鉴定出来的化合物占总峰面积的77.6%，洋葱油中化合物总数的29.2%。结果显示，脱水洋葱粉提取的洋葱挥发油的主要成分是3, 5-二乙基-1, 2, 4-三硫环戊烷，4-甲基-4-羟基戊酮，6-氨基-1, 3, 5-三嗪基-2, 4-二酚和3, 4-二甲基噻吩等含硫化合物，与文献中一般提及的以硫醚类化合物为主的洋葱有所差异。 关键词：洋葱；超临界流体；萃取；气相色谱-质谱联用 Abstract : This article mainly discuss the active substance (onion oil) in Allium cepa L. and the relative content of various substances. Taking into account the active material in fresh onion in the content is extremely low, we decide to buy dehydraed onion powder instead. In the meanwhile, some components in onion are heat-sensitive materials, in order not to damage those active substance, we finally determine to adopt the preparation method of supercritical carbon dioxide extraction of onion oil. After analyzed by GC/MS, 65 peaks were separated from the oil.and 19 compounds were identified.Some chemicals were the first time separated from the plant.These compounds identified took up 77.6% of the total areas and 29.2% of all compounds.The results showed that main compounds of Chinese Allium cepa L. were the main 3,5-diethyl-1,2,4-trithiane, 4-hydroxy-4-methyl-2-pentanone, 6-amino-1H- [1,3,5]triazine-2,4-dione, 3,4-dimethylthiophene and other thianes, thiols, sulfides.. These compounds were partly different from these of the same over sea species which had sulfoethers as main components. Keywords : Onion；Supercritical fluid；Extraction；GC/MS
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非诺贝特酸胆碱的制备_制药工程论文范文
制药工程论文范文 目 录 中文摘要I 英文摘要II 目录III 1. 绪论1 1.1 研究的背景1 1.2 研究的意义1 1.3 胆碱简介3 1.4 非诺贝特酸简介4 1.5 胆碱盐及其合成方法介绍4 2. 实验部分8 2.1 实验原理8 2.2 实验试剂10 2.3 实验仪器 10 2.4 实验基本操作10 2.5 产物分析10 3. 结果与讨论10 3.1 实验结果10 3.2 实验讨论11 4．总结与展望15 致谢17 参考文献18 附录20 摘要：非诺贝特酸胆碱是一种新型降脂药物。本论文提出一条新的制备非诺贝特酸胆碱的原料路线，即三甲胺和非诺贝特酸在异丙醇作溶剂条件下，首先酸碱中和反应成盐，然后该盐在H+的催化下再与环氧乙烷反应生产氢氧化胆碱盐。这是一个自催化反应。实验中，我们详细研究了反应物配比、溶剂种类、反应时间、加料时间及加料速度等因素对产品纯度及产率的影响。在最佳工艺条件下，得到精制后产品质量20.93g，最终收率达95%以上。产物结构由IR得到证明，产品用HPLC进行分析，纯度为99.80%。 关键词：非诺贝特酸胆碱；胆碱；自催化；有机合成 Abstract：The Choline Fenofibrate Acid is a new type of lipid-lowering drugs.In this study,a new material route for preparation of Choline Fenofibrate Acid was provided. That is using Trimethylamine and Fenofibrate Acid to prepare salt in the Isopropanol, then using the salt and Ethylene Oxide to synthesize Choline Hydroxide salt and H+ as catalyst. This is a selfcatalysis reaction. In the experimental, the conditions of synthesis such as proportions, kinds of solvents, reaction time, feeding times, feeding speeds and etc.were investigated in detail and see the impact on the purity and the yield. In the best conditions,the quality of refined product is 20.93g, and the yield was reached more than 95%.The structure of the product was confirmed by IR,and the product was analysised with HPLC and the purity was morn than 99.8%. Keywords: Choline fenofibrate acid; Choline; Selfcatalysis;Organic synthesis
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硝酸锌的车间生产工艺设计_制药工程论文范文
制药工程论文范文 目 录 中文摘要I 英文摘要II 目录III 1. 总论1 1.1 概述1 1.2 生产工艺介绍2 2. 工艺计算3 2.1 物料衡算3 2.2 能量衡算6 3. 主要设备计算及选型7 3.1 反应釜容积计算及选型7 3.2 原料储罐容积的计算及选型7 3.3 泵的选型7 3.4 离心机选型8 4. 三废处理8 4.1 废气处理8 4.2 废渣处理8 4.3 废液处理8 5．厂址选择8 6. 车间人员安排9 致谢10 参考文献11 附录 摘 要：本论文是对年产2000吨硝酸锌的车间工艺的设计，其中包括工艺流程图的设计、物料衡算、能量衡算、设备设计等内容。 关键词：硝酸锌；车间工艺；设计 Abstract: In this dissertation, we designed workshop process for production of Zinc nitrate. It included process flow diagram, process figure, material balance, workshop layout and equipment, diameter calculated, such as a list. Keywords：Zinc nitrate；Workshop Process；Desig
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姜黄素－壳聚糖纳米粒的制备_制药工程论文范文
制药工程论文范文 目 录 中文摘要………………………………………………………………………………………… I 英文摘要 ……………………………………………………………………………………… II 目录 ………………………………………………………………………………………… III 1．绪论 ………………………………………………………………………………………… 1 1.1 前言…………………………………………………………………………………… 1 1.1.1姜黄素的结构与性质………………………………………………………… 1 1.1.2姜黄素的研究现状……………………………………………………………1 1.1.3壳聚糖的结构与性质…………………………………………………………2 1.1.4壳聚糖作为药物载体的优点…………………………………………………3 1.1.5壳聚糖作为药物载体的应用…………………………………………………3 1.2研究方法现状 …………………………………………………………………………5 1.2.1共价交联法……………………………………………………………………5 1.2.2沉淀法或凝聚法………………………………………………………………5 1.2.3喷雾干燥法……………………………………………………………………5 1.2.4模板聚合法……………………………………………………………………5 1.2.5乳滴聚结法……………………………………………………………………6 1.3实验课题方案 …………………………………………………………………………6 2. 实验部分 …………………………………………………………………………………… 8 2.1 实验仪器与试剂……………………………………………………………………… 8 2.2 实验内容 …………………………………………………………………………… 9 2.2.1姜黄素的测定 ……………………………………………………………… 9 2.2.2壳聚糖纳米粒的制备………………………………………………………… 9 2.2.3姜黄素-壳聚糖纳米粒的制备 ……………………………………………… 9 2.2.4优化工艺……………………………………………………………………… 9 2.2.5包封率、载药量的测定 ……………………………………………………10 2.2.6纳米粒径的测定…………………………………………………………… 10 2.2.7稳定性分析 ………………………………………………………………… 11 3. 结果与讨论………………………………………………………………………………… 12 3.1 姜黄素标准曲线 …………………………………………………………………… 12 3.2 单因素考察结果 …………………………………………………………………… 12 3.2.1 壳聚糖浓度对制备载药纳米粒的影响…………………………………… 12 3.2.2 TPP浓度对制备载药纳米粒的影响 ……………………………………… 13 3.2.3 溶液pH值对制备载药纳米粒的影响 …………………………………… 14 3.2.4 姜黄素浓度对制备载药纳米粒的影响 ………………………………… 14 3.2.5 TPP滴加速度对制备载药纳米粒的影响 ………………………………… 15 3.2.6搅拌速度、时间对制备载药纳米粒的影响………………………………… 15 3.2.7冻干保护剂对制备载药纳米粒的影响 …………………………………… 16 3.3姜黄素-壳聚糖纳米粒径大小分布…………………………………………………17 3.3.1壳聚糖空白纳米粒径大小分布 ……………………………………………17 3.3.2载药壳聚糖纳米溶液粒径大小分布 ………………………………………17 3.3.3载药壳聚糖纳米冻干粉末粒径大小分布 …………………………………18 3.3.4载药壳聚糖纳米粒径稳定性分析 …………………………………………22 4. 总结与展望 ………………………………………………………………………………24 4.1总结 …………………………………………………………………………………24 4.2展望 …………………………………………………………………………………24 致谢 ……………………………………………………………………………………………25 参考文献 ………………………………………………………………………………………26 摘要：制备姜黄素壳-聚糖纳米粒，并对其制备工艺进行考察。以壳聚糖(CS)作载体，与三聚磷酸钠(TPP)发生离子交联反应，把药物包裹在里面，制备具有缓释效能的姜黄素-壳聚糖纳米粒，并以载药量、颗粒粒径为指标，研究一系列壳聚糖纳米粒的制备影响因素，通过正交实验得出纳米粒的最佳制备工艺条件，并应用激光散射测定仪测定纳米粒的粒径分布。成功制备姜黄素-壳聚糖的纳米粒，平均粒径220nm，包封率10%左右，平均载药量30%。壳聚糖浓度、体系的pH值、TPP浓度，冻干保护剂是影响制备工艺的主要因素。 关键词：姜黄素；壳聚糖；纳米粒；三聚磷酸钠 Abstract: To prepare Curcumin-chitosan nanoparticles and study their preparation method. The drugs Curcumin- Chitosan(CS) Nanoparticles have been formed based on ionic gelation process of tripolyphosphate (TPP) and chitosan. Drug-loading rate and particle size as the indices to study a series of preparation effect factors of chitosan nanoparticles. The orthogonal experimental design applied to optimize the preparation procedure of the nanoparticles. The particle size distribution of nanoparticles was measured by laser scattering apparatus. The stable Curcumin-chitosan nanoparticles was prepared. Average size of 220 nm, Encapsulation efficiency 10%，Average Drug-loading rate 30%. Chitosan concentration, pH value of the system, Sodium Tripolyphosphate(TPP) concentration, Lyoprotectents are all the main effect factors of nanoparticles preparation. Keywords: Curcumin；Chitosan；Nanoparticles；Sodium Tripolyphosphate
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药品淘汰与市场监管_制药工程论文范文
制药工程论文范文 目 录 中文摘要I 英文摘要II 目录III 1. 绪论1 1.1 药品淘汰概述1 1.2 药品淘汰的目的2 1.3 药品淘汰的必要性与紧迫性2 1.4 药品淘汰的现状2 2. 查阅部分3 2.1 国内最近十年所淘汰的药品3 2.2 国际上最近十年所淘汰的药品4 2.3 药品淘汰的根据5 2.4 国内药品淘汰工作的法律、法规依据6 2.5 药品淘汰的程序9 2.6 国外药品淘汰的机构、技术机构和人员以及他们工作的程序10 3. 讨论与建议12 3.1 国内这项工作的缺陷、漏洞、他们的原因12 3.2 对策和建议14 4．总结与展望16 致谢17 参考文献18 附表A20 附表B21 附表C24 摘要：药品淘汰制度是减少存在安全隐患的药品对公众用药安全造成危害的一种行之有效的手段。美国、日本、加拿大等许多国家和地区已经建立并成功实施。近年来，我国药品行业安全事故不断，促使人们更加关注药品安全问题，建立药品淘汰制度的呼声也日益强烈。药品淘汰应是一种在国家指导下的经济责任。在我国实施药品淘汰的障碍主要在于药品缺陷的认定困难以及生产者的抵制、药监部门的无能和消费者的漠视，可通过改组制药企业、完善法律制度、加强监管、建立风险转移机制等方式加以解决。 关键词：淘汰药品；组织机构 ；药品监管 Abstract ：Drugs out of the system is to reduce the existence of drug safety to the public security administration. Harm the whole an effective means of, the United States, Japan, Canada and many other countries and regions have been established and successfully implemented. In recent years, China's pharmaceutical industry continued security incidents, people have paid closer attention to the issue of drug safety, the establishment of the voice of medicine out of the system also increased. Drugs should be a kind of out of the country's economy under the guidance of Green office. Drugs in our country out of the obstacles to the implementation of the main defect lies in drugs, as well as the difficulties that the resistance of producers, Drug sector incompetence and disregard for the consumer, pharmaceutical companies through restructuring, improving the legal system, strengthen supervision, the establishment of risk transfer mechanisms way to sort them out. Keywords：Out of Drug ;Organization ;Drug Supervision
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对乙酰氨基酚的含量测定及有关物质检查_制药工程论文
制药工程论文范文 目 录 1. 绪论 ………………………………………………………… 1 1.1 对乙酰氨基酚………………………………………… 1 1.2 选题背景与意义……………………………………… 1 1.3 含量测定方法………………………………………… 2 2. 实验部分 …………………………………………………… 4 2.1 高效液相色谱法……………………………………… 4 2.2 紫外分光光度法……………………………………… 6 3. 结果与讨论 ………………………………………………… 7 3.1 结果…………………………………………………… 7 3.2 讨论…………………………………………………… 12 4. 总结与展望 ………………………………………………… 13 致谢 ……………………………………………………………… 14 参考文献 ………………………………………………………… 15 摘要：本论文建立对乙酰氨基酚含量测定的方法。采用高效液相色谱法和紫外分光光度法。高效液相色谱法以C18为色谱柱，以甲醇-水 (体积比70∶30)为流动相，流速为1.0 mL／min，检测波长为250 nm。对乙酰氨基酚在5～30 μg／mL浓度范围内呈现良好的线性关系(r=0.9997)，回收率为99.6％（RSD=1.9％)。在该色谱条件下对对乙酰氨基酚的杂质对氨基酚进行检查，对氨基酚线性范围0.1 μg/mL ～1.2 μg/mL。紫外分光光度法测定对乙酰氨基酚含量，结果表明，对乙酰氨基酚在2～10 ug／mL范围内线性关系良好，平均回收率为99.9％(RSD=1.1％)。我们建立的两种含量方法操作简便，灵敏度高，重复性好，测定结果准确，可用于对乙酰氨基酚的含量测定。 关键词： 对乙酰氨基酚；对氨基酚；高效液相色谱法；紫外分光光度法 Abstract : The purpose of this article was to establish methods for content determination of acetaminophen. We used High-performance liquid chromatography and ultraviolet spectrophotometry. Chromatographic conditions were C18 column and methanol-water (volume ratio 70:30) as the mobile phase. The flow rate was 1.0 mL / min and the detection wavelength was 250nm. In the range of 5～30 μg／mL, acetaminophen’s concentration showed a good linear relationship (r = 0.9997). The recovery ratio was 99.6% (RSD = 1.9%). The p-aminophenol was detected under the same conditions and its linear range was 0.1μg/mL~1.2μg/mL. UV spectrophotometry was used to determine the content of acetaminophen. In the range of 1~10ug/mL, the concentration showed a good linear relationship and the average recovery ratio was 99.9%(RSD = 1.1%). The two methods were simple, sensitive, reproducible and accurate, which can be used in the content determination of acetaminophen. Key words： Acetaminophen；p-Aminophenol ；HPLC； UV spectrophotometry
