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摘要翻译：
更强的流感病毒亚型H1N1在2007年和H3N2在2011年广泛出现，尤其是2013-4年，当时H3N2疫苗的效力几乎降至零。通过序列比对和位点同源性和相似性计数，将神经氨酸酶与先前毒力较低的菌株的氨基酸差异显示为很小(<1%)。在这里，我们展示了如何分析神经氨酸酶球状压实和模块化的分形水病理力来量化毒性增加的突变起源。它还预测了疫苗逃逸，并为2015年H3N2疫苗指定了不同于世界卫生组织目标的优化目标。与早期一些基于测量血凝素抗原漂移和雪貂血清的方法不同，这些方法需要数年时间，只覆盖少数候选菌株，而且模糊不清，新方法是及时的，可以在几天内完成，只使用NCBI和GISAID氨基酸序列。
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英文标题：
《Vaccine escape in 2013-4 and the hydropathic evolution of glycoproteins
of A/H3N2 viruses》
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作者：
J. C. Phillips
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最新提交年份：
2015
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分类信息：
一级分类：Quantitative Biology 数量生物学
二级分类：Other Quantitative Biology 其他定量生物学
分类描述：Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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英文摘要：
More virulent strains of influenza virus subtypes H1N1 appeared widely in 2007 and H3N2 in 2011, and especially 2013-4, when the effectiveness of the H3N2 vaccine decreased nearly to zero. The amino acid differences of neuraminidase from prior less virulent strains appear to be small (<1%) when tabulated through sequence alignments and counting site identities and similarities. Here we show how analyzing fractal hydropathic forces responsible for neuraminidase globular compaction and modularity quantifies the mutational origins of increased virulence. It also predicts vaccine escape and specifies optimized targets for the 2015 H3N2 vaccine different from the WHO target. Unlike some earlier methods based on measuring hemagglutinin antigenic drift and ferret sera, which take several years, cover only a few candidate strains, and are ambiguous, the new methods are timely and can be completed, using NCBI and GISAID amino acid sequences only, in a few days.
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PDF链接：
https://arxiv.org/pdf/1508.07244
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