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摘要翻译：
我们提出了一种改进的间期染色质双角模型(E2A模型）。该模型考虑了组蛋白八聚体的圆柱形、H1组蛋白在核小体前面的位置以及DNA链与DNA链之间的垂直距离D$。考虑这些染色质特征，我们可以得到染色质相图的本质变化：不仅排除体积边界的形状发生变化，而且垂直距离D$对禁区也有很大的影响。此外，我们还研究了H1缺陷对染色质纤维性能的影响。因此，我们提出了两种可能的染色质压缩策略：在相图中的间隙中使用非常致密的状态，在排除体积边界或缺失的H1组蛋白中使用非常致密的状态，这可以导致非常致密的纤维。染色质纤维可能利用这两种机制来至少局部致密。在模型内计算的线密度与实验值相吻合。
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英文标题：
《The influence of the cylindrical shape of the nucleosomes and H1 defects
on properties of chromatin》
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作者：
P.M.Diesinger and D.W.Heermann
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最新提交年份：
2007
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分类信息：
一级分类：Physics 物理学
二级分类：Soft Condensed Matter 软凝聚态物质
分类描述：Membranes, polymers, liquid crystals, glasses, colloids, granular matter
膜，聚合物，液晶，玻璃，胶体，颗粒物质
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一级分类：Physics 物理学
二级分类：Statistical Mechanics 统计力学
分类描述：Phase transitions, thermodynamics, field theory, non-equilibrium phenomena, renormalization group and scaling, integrable models, turbulence
相变，热力学，场论，非平衡现象，重整化群和标度，可积模型，湍流
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一级分类：Quantitative Biology 数量生物学
二级分类：Subcellular Processes 亚细胞过程
分类描述：Assembly and control of subcellular structures (channels, organelles, cytoskeletons, capsules, etc.); molecular motors, transport, subcellular localization; mitosis and meiosis
亚细胞结构（通道、细胞器、细胞骨架、囊膜等）的组装和控制；分子马达；转运；亚细胞定位；有丝分裂和减数分裂
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英文摘要：
We present a model improving the two-angle model for interphase chromatin (E2A model). This model takes into account the cylindrical shape of the histone octamers, the H1 histones in front of the nucleosomes and the vertical distance $d$ between the in and outgoing DNA strands. Factoring these chromatin features in, one gets essential changes in the chromatin phase diagram: Not only the shape of the excluded-volume borderline changes but also the vertical distance $d$ has a dramatic influence on the forbidden area. Furthermore, we examined the influence of H1 defects on the properties of the chromatin fiber. Thus we present two possible strategies for chromatin compaction: The use of very dense states in the phase diagram in the gaps in the excluded volume borderline or missing H1 histones which can lead to very compact fibers. The chromatin fiber might use both of these mechanisms to compact itself at least locally. Line densities computed within the model coincident with the experimental values.
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PDF链接：
https://arxiv.org/pdf/705.2215
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