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摘要翻译：
成瘾的神经机制一直受到神经生物学、经济学、神经精神病学和神经经济学的关注。本文根据成瘾的神经经济学和神经生物学的最新发现，提出了成瘾的经济理论（Becker and Murphy，1988)和双向突触可塑性的神经生物学理论（Bienenstock,Cooper,Munro，1982)之间可能的联系。此外，在Becker和Murphy的成瘾经济学理论中，几种神经生物学底物如皮质醇（一种应激激素）、NMDA和AMPA受体/亚基以及突触后神经元的胞内钙是决定参数的关键因素。讨论了该理论在成瘾及其与应激关系的神经经济学和神经精神病学研究中的未来应用方向。
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英文标题：
《A neuroeconomic theory of bidirectional synaptic plasticity and
addiction》
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作者：
Taiki Takahashi
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最新提交年份：
2011
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分类信息：
一级分类：Quantitative Biology 数量生物学
二级分类：Neurons and Cognition 神经元与认知
分类描述：Synapse, cortex, neuronal dynamics, neural network, sensorimotor control, behavior, attention
突触，皮层，神经元动力学，神经网络，感觉运动控制，行为，注意
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一级分类：Quantitative Biology 数量生物学
二级分类：Other Quantitative Biology 其他定量生物学
分类描述：Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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英文摘要：
Neuronal mechanisms underlying addiction have been attracting attention in neurobiology, economics, neuropsychiatry, and neuroeconomics. This paper proposes a possible link between economic theory of addiction (Becker and Murphy, 1988) and neurobiological theory of bidirectional synaptic plasticity (Bienenstock, Cooper, Munro, 1982) based on recent findings in neuroeconomics and neurobiology of addiction. Furthermore, it is suggested that several neurobiological substrates such as cortisol (a stress hormone), NMDA and AMPA receptors/subunits and intracellular calcium in the postsynaptic neurons are critical factors determining parameters in Becker and Murphy's economic theory of addiction. Future directions in the application of the theory to studies in neuroeconomics and neuropsychiatry of addiction and its relation to stress at the molecular level are discussed.
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PDF链接：
https://arxiv.org/pdf/1111.6495
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