寿命老化的热力学机制

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摘要翻译：
生命是一种复杂的生物现象，由生物热力学系统/细胞/生物体所执行的众多化学、物理和生物过程所代表。生物有机体和无生命的物体都经历了衰老，衰老是一个以生物和热力学状态变化为特征的生物和物理化学过程。因此，同样的物理规律支配着有生命和无生命物质的过程。所有的生命过程都会导致生物体状态的变化。生物体的生物和热力学状态随时间的变化构成了所有三种衰老（时间衰老、生物衰老和热力学衰老）的基础。生物的生命和衰老都始于受精的那一刻，并持续到整个生命周期。受精代表一个新有机体的形成。新生物体代表了一个新的热力学系统。从一开始，它就通过改变热力学参数来改变状态。随着老化，热力学参数的变化与熵的变化有关。因此，熵是与所有其他参数相关的参数，并以最好的方式描述衰老。起初，熵变是物质积累（生长）的结果。后来，分解和构型变化占主导地位，这是各种化学反应（自由基、分解、碎裂、脂褐素样物质的积累……)的结果。
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英文标题：
《Thermodynamic Mechanism of Life and Aging》
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作者：
Marko Popovic
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最新提交年份：
2018
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分类信息：

一级分类：Quantitative Biology        数量生物学
二级分类：Other Quantitative Biology        其他定量生物学
分类描述：Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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一级分类：Physics        物理学
二级分类：Biological Physics        生物物理学
分类描述：Molecular biophysics, cellular biophysics, neurological biophysics, membrane biophysics, single-molecule biophysics, ecological biophysics, quantum phenomena in biological systems (quantum biophysics), theoretical biophysics, molecular dynamics/modeling and simulation, game theory, biomechanics, bioinformatics, microorganisms, virology, evolution, biophysical methods.
分子生物物理、细胞生物物理、神经生物物理、膜生物物理、单分子生物物理、生态生物物理、生物系统中的量子现象（量子生物物理）、理论生物物理、分子动力学/建模与模拟、博弈论、生物力学、生物信息学、微生物、病毒学、进化论、生物物理方法。
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一级分类：Quantitative Biology        数量生物学
二级分类：Tissues and Organs        组织器官
分类描述：Blood flow in vessels, biomechanics of bones, electrical waves, endocrine system, tumor growth
血管内血流，骨骼生物力学，电波，内分泌系统，肿瘤生长
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英文摘要：
  Life is a complex biological phenomenon represented by numerous chemical, physical and biological processes performed by a biothermodynamic system/cell/organism. Both living organisms and inanimate objects are subject to aging, a biological and physicochemical process characterized by changes in biological and thermodynamic state. Thus, the same physical laws govern processes in both animate and inanimate matter. All life processes lead to change of an organism's state. The change of biological and thermodynamic state of an organism in time underlies all of three kinds of aging (chronological, biological and thermodynamic). Life and aging of an organism both start at the moment of fertilization and continue through entire lifespan. Fertilization represents formation of a new organism. The new organism represents a new thermodynamic system. From the very beginning, it changes its state by changing thermodynamic parameters. The change of thermodynamic parameters is observed as aging and can be related to change in entropy. Entropy is thus the parameter that is related to all others and describes aging in the best manner. In the beginning, entropy change appears as a consequence of accumulation of matter (growth). Later, decomposition and configurational changes dominate, as a consequence of various chemical reactions (free radical, decomposition, fragmentation, accumulation of lipofuscin-like substances...).
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PDF链接：
https://arxiv.org/pdf/1801.08073

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关键词：热力学 Quantitative accumulation QUANTITATIV composition chemical 方式 改变 物质 new