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摘要翻译：
关于人类衰老的新的经验和理论思考相当重视环境作为促进长期健康长寿的一个主要因素的作用。我们当代的、信息丰富的环境不仅意味着一个人的实际物理环境，而且还被认为是更抽象的意义上的，指文化、社会和技术的影响。我们的现代环境远非一成不变或稳定的。事实上，它正以指数的方式不断变化，需要代表我们的发展和进化机制做出持续的适应性反应。在这篇论文中，我试图描述一个持续的、平衡的和有意义的暴露在一个刺激环境中，包括暴露在需要行动的信息（但不是微不足道的信息）中，如何对表观遗传机制产生直接或间接的影响，从而延长健康的寿命。从我们的环境中获得的信息就像一种刺激，它提高了生物反应和反馈循环，最终导致改善与年龄相关的损伤的修复。这种生物信息处理机制的结果可能会影响资源分配，并纠正体细胞与生殖细胞修复之间的不平衡。这最终会产生进化的后果，导致与年龄相关的疾病和退化的大幅减少。
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英文标题：
《Information -sharing, adaptive epigenetics and human longevity》
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作者：
Marios Kyriazis
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最新提交年份：
2014
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分类信息：
一级分类：Quantitative Biology 数量生物学
二级分类：Other Quantitative Biology 其他定量生物学
分类描述：Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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英文摘要：
Emerging empirical and theoretical thinking about human aging places considerable value upon the role of the environment as a major factor which can promote prolonged healthy longevity. Our contemporary, information-rich environment is taken to mean not merely the actual physical surroundings of a person but it is also considered in a more abstract sense, to denote cultural, societal and technological influences. Our modern environment is far from being static or stable. In fact, it is continually changing in an exponential manner, necessitating constant adaptive responses on behalf of our developmental and evolutionary mechanisms. In this paper, I attempt to describe how a continual, balanced and meaningful exposure to a stimulating environment, including exposure to information-that-requires-action (but NOT trivial information), has direct or indirect repercussions on epigenetic mechanisms which may then act to prolong healthy longevity. Information gained from our environment acts as a hormetic stimulus which up-regulates biological responses and feedback loops, eventually leading to improved repair of age-related damage. The consequence of this biological information-processing mechanism may influence resource allocation and redress the imbalance between somatic cell versus germ-line cell repairs. This can eventually have evolutionary consequences resulting in the drastic reduction of age-related disease and degeneration.
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PDF链接：
https://arxiv.org/pdf/1407.6030
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