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摘要翻译：
在DNA代谢的大多数重要过程中，蛋白质必须到达DNA上的特定结合位点。特定的结合位点可能只有几个碱基对，而DNA通常有几百万个碱基对长。蛋白质是如何搜索目标位点的？成功搜索的最有效机制是什么？在这些细胞内生物过程的基本问题的推动下，我们开发了一个用单个蛋白质在模型DNA上搜索特定位点的模型。我们对在DNA上寻找特定位点的过程中，粒子的滑动、节间跳跃和分离/再附着的效率进行了比较定量的研究。我们还通过定义一个相关的量，引入了一些新的搜索过程的{it效率}的定量度量，这些度量可以在{it体外实验}中测量。
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英文标题：
《Searching for targets on a model DNA: Effects of inter-segment hopping,
detachment and re-attachment》
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作者：
Debanjan Chowdhury
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最新提交年份：
2010
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分类信息：
一级分类：Physics 物理学
二级分类：Statistical Mechanics 统计力学
分类描述：Phase transitions, thermodynamics, field theory, non-equilibrium phenomena, renormalization group and scaling, integrable models, turbulence
相变，热力学，场论，非平衡现象，重整化群和标度，可积模型，湍流
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一级分类：Quantitative Biology 数量生物学
二级分类：Biomolecules 生物分子
分类描述：DNA, RNA, proteins, lipids, etc.; molecular structures and folding kinetics; molecular interactions; single-molecule manipulation.
DNA、RNA、蛋白质、脂类等；分子结构与折叠动力学；分子相互作用；单分子操作。
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英文摘要：
For most of the important processes in DNA metabolism, a protein has to reach a specific binding site on the DNA. The specific binding site may consist of just a few base pairs while the DNA is usually several millions of base pairs long. How does the protein search for the target site? What is the most efficient mechanism for a successful search? Motivated by these fundamental questions on intracellular biological processes, we have developed a model for searching a specific site on a model DNA by a single protein. We have made a comparative quantitative study of the efficiencies of sliding, inter-segmental hoppings and detachment/re-attachments of the particle during its search for the specific site on the DNA. We also introduce some new quantitative measures of {\it efficiency} of a search process by defining a relevant quantity, which can be measured in {\it in-vitro} experiments.
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PDF链接：
https://arxiv.org/pdf/708.1931
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