基于混沌博弈的冠状病毒家系比较基因组分析 表示与Fisher-Shannon复杂性

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摘要翻译：
自2019年12月在中国武汉首次出现以来，新冠肺炎疫情在全球范围内引发了前所未有的健康危机。新型冠状病毒病是由严重急性呼吸系统综合征冠状病毒2（新型冠状病毒）引起的，属于冠状病毒科。本文采用混沌博弈表示和Fisher-Shannon复杂度（CGR-FSC）方法，对人类冠状病毒OC43(HCoV-OC43)、人类冠状病毒HKU1(HCoV-HKU1)、人类冠状病毒229E(HCoV-229E)、人类冠状病毒NL63(HCoV-NL63)、严重急性呼吸综合征冠状病毒(SARS-CoV)、中东呼吸综合征相关冠状病毒(MERS-CoV)、严重急性呼吸综合征冠状病毒2（新型冠状病毒）和蝙蝠冠状病毒RaTG13等8种冠状病毒进行了比较基因组分析。混沌博弈表示(CGR)是一种独特的无比对的DNA序列二维分形可视化方法。然后用Fisher-Shannon复杂度(FSC)测度对二维CGR模式进行量化。CGR-FSC能有效地对病毒进行唯一识别，并能在Fisher-Shannon信息平面(FSIP)上揭示病毒的相似性/差异性。
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英文标题：
《A Comparative Genomic Analysis of Coronavirus Families Using Chaos Game
  Representation and Fisher-Shannon Complexity》
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作者：
S. K. Laha
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最新提交年份：
2021
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分类信息：

一级分类：Quantitative Biology        数量生物学
二级分类：Other Quantitative Biology        其他定量生物学
分类描述：Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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英文摘要：
  From its first emergence in Wuhan, China in December, 2019 the COVID-19 pandemic has caused unprecedented health crisis throughout the world. The novel coronavirus disease is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which belongs to the coronaviridae family. In this paper, a comparative genomic analysis of eight coronaviruses namely Human coronavirus OC43 (HCoV-OC43), Human coronavirus HKU1 (HCoV-HKU1), Human coronavirus 229E (HCoV-229E), Human coronavirus NL63 (HCoV-NL63), Severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome-related coronavirus (MERS-CoV), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and Bat coronavirus RaTG13 has been carried out using Chaos Game Representation and Fisher-Shannon Complexity (CGR-FSC) measure. Chaos Game Representation (CGR) is a unique alignment-free method to visualize one dimensional DNA sequence in a two-dimensional fractal-like pattern. The two-dimensional CGR pattern is then quantified by Fisher-Shannon Complexity (FSC) measure. The CGR-FSC can effectively identify the viruses uniquely and their similarity/dissimilarity can be revealed in the Fisher-Shannon Information Plane (FSIP).
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PDF链接：
https://arxiv.org/pdf/2107.06282

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关键词：Shannon Fisher Shan Fish SHE FSC 新冠 Representation Complexity 综合征