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摘要翻译：
所谓混合反馈环(MFL)是一个小的双基因网络，其中a蛋白调节B蛋白的转录，两个蛋白形成异源二聚体。在基因和蛋白质相互作用数据库的统计分析中，它被发现在统计学上被过度代表，并处于几个计算机生成的遗传网络的核心。在这里，我们提出并数学地研究了漏磁激光器的模型，并证明了它本身既可以作为双稳开关，又可以作为时钟（振荡器），这取决于动力学参数。给出了磁流变相图和非线性振荡区的详细描述，并讨论了一些生物例子。这些结果强调了蛋白质相互作用在遗传模块功能中的作用，以及明确模拟RNA动态的有用性。
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英文标题：
《A core genetic module : the Mixed Feedback Loop》
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作者：
Paul Francois and Vincent Hakim
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最新提交年份：
2005
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分类信息：
一级分类：Quantitative Biology 数量生物学
二级分类：Molecular Networks 分子网络
分类描述：Gene regulation, signal transduction, proteomics, metabolomics, gene and enzymatic networks
基因调控、信号转导、蛋白质组学、代谢组学、基因和酶网络
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一级分类：Quantitative Biology 数量生物学
二级分类：Other Quantitative Biology 其他定量生物学
分类描述：Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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英文摘要：
The so-called Mixed Feedback Loop (MFL) is a small two-gene network where protein A regulates the transcription of protein B and the two proteins form a heterodimer. It has been found to be statistically over-represented in statistical analyses of gene and protein interaction databases and to lie at the core of several computer-generated genetic networks. Here, we propose and mathematically study a model of the MFL and show that, by itself, it can serve both as a bistable switch and as a clock (an oscillator) depending on kinetic parameters. The MFL phase diagram as well as a detailed description of the nonlinear oscillation regime are presented and some biological examples are discussed. The results emphasize the role of protein interactions in the function of genetic modules and the usefulness of modelling RNA dynamics explicitly.
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PDF链接：
https://arxiv.org/pdf/q-bio/0507044
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