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摘要翻译：
单个基因通过正反馈环调节自身的表达，构成了基因调控网络和信号级联中的一个共同的基序。最近关于枯草杆菌种群能力发展的实验表明，自调节遗传模块本身可以产生两种类型的细胞状态。所述状态对应于主调节器COMK的低表达状态和高表达状态。当ComK蛋白水平超过阈值，导致自刺激环完全激活时，达到高表达状态。基因表达的随机性驱动着两种稳定状态之间的转换。本文在三种可能的情形下，解释了EMPH{B.subtilis}细胞群体中蛋白质双峰分布的出现。在其中两种情况下，双稳态为双基因表达提供了基础。在第三种情况下，系统在确定性描述中是单稳态的，基因表达的随机性完全负责这两种表达状态的出现。
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英文标题：
《Positive Feedback, Stochasticity and Genetic Competence》
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作者：
Rajesh Karmakar and Indrani Bose
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最新提交年份：
2007
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分类信息：
一级分类：Quantitative Biology 数量生物学
二级分类：Quantitative Methods 定量方法
分类描述：All experimental, numerical, statistical and mathematical contributions of value to biology
对生物学价值的所有实验、数值、统计和数学贡献
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一级分类：Physics 物理学
二级分类：Statistical Mechanics 统计力学
分类描述：Phase transitions, thermodynamics, field theory, non-equilibrium phenomena, renormalization group and scaling, integrable models, turbulence
相变，热力学，场论，非平衡现象，重整化群和标度，可积模型，湍流
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一级分类：Quantitative Biology 数量生物学
二级分类：Other Quantitative Biology 其他定量生物学
分类描述：Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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英文摘要：
A single gene, regulating its own expression via a positive feedback loop, constitutes a common motif in gene regulatory networks and signalling cascades. Recent experiments on the development of competence in the bacterial population \emph{B. subtilis} show that the autoregulatory genetic module by itself can give rise to two types of cellular states. The states correspond to the low and high expression states of the master regulator ComK. The high expression state is attained when the ComK protein level exceeds a threshold value leading to a full activation of the autostimulatory loop. Stochasticity in gene expression drives the transitions between the two stable states. In this paper, we explain the appearance of bimodal protein distributions in \emph{B. subtilis} cell population in the framework of three possible scenarios. In two of the cases, bistability provides the basis for binary gene expression. In the third case, the system is monostable in a deterministic description and stochasticity in gene expression is solely responsible for the appearance of the two expression states.
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PDF链接：
https://arxiv.org/pdf/q-bio/0702055
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