摘要翻译:
研究了结构无序对以环形式服从机械/拓扑约束的二维弹性链热力学性质的影响。无序是通过自发曲率引入的,该曲率沿链的分布呈现无相关或长程相关(LRC)。对于弱无序,用数值和解析方法导出了单环系统的平衡性质。LRC有利于小环的形成,LRC越大,环的尺寸越小。我们用平均首次通过时间的形式证明了在存在LRC的情况下,典型的短时环动力学是超扩散的。讨论了核小体在真核染色质中的定位和动力学的潜在生物学意义。
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英文标题:
《Thermodynamics of DNA loops with long-range correlated structural
disorder》
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作者:
C\'edric Vaillant (SG), Benjamin Audit (Phys-ENS), Alain Arn\'eodo
(Phys-ENS)
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最新提交年份:
2007
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分类信息:
一级分类:Quantitative Biology 数量生物学
二级分类:Genomics 基因组学
分类描述:DNA sequencing and assembly; gene and motif finding; RNA editing and alternative splicing; genomic structure and processes (replication, transcription, methylation, etc); mutational processes.
DNA测序与组装;基因和基序的发现;RNA编辑和选择性剪接;基因组结构和过程(复制、转录、甲基化等);突变过程。
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一级分类:Physics 物理学
二级分类:Statistical Mechanics 统计力学
分类描述:Phase transitions, thermodynamics, field theory, non-equilibrium phenomena, renormalization group and scaling, integrable models, turbulence
相变,热力学,场论,非平衡现象,重整化群和标度,可积模型,湍流
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英文摘要:
We study the influence of a structural disorder on the thermodynamical properties of 2D-elastic chains submitted to mechanical/topological constraint as loops. The disorder is introduced via a spontaneous curvature whose distribution along the chain presents either no correlation or long-range correlations (LRC). The equilibrium properties of the one-loop system are derived numerically and analytically for weak disorder. LRC are shown to favor the formation of small loop, larger the LRC, smaller the loop size. We use the mean first passage time formalism to show that the typical short time loop dynamics is superdiffusive in the presence of LRC. Potential biological implications on nucleosome positioning and dynamics in eukaryotic chromatin are discussed.
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PDF链接:
https://arxiv.org/pdf/710.4398