摘要翻译:
泛素在不到50年前被发现,它标记了数千种疾病蛋白质以进行破坏。它很小(只有76个氨基酸),在哺乳动物、鸟类、鱼类甚至蠕虫中都没有发现变化。利用临界点热力学标度理论确定了其功能的关键特征。其中包括球状表面形状转变的一阶和二阶元素之间的Fano干涉。与它的近亲76个氨基酸Nedd8相比,后者缺乏这些特征。针对多个病变蛋白所共享的共同靶点,提出了一种裂纹弹性网络模型。
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英文标题:
《Configuration Interaction of Hydropathic Waves Enables Ubiquitin
Functionality》
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作者:
Douglas C. Allan and J. C. Phillips
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最新提交年份:
2016
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分类信息:
一级分类:Quantitative Biology 数量生物学
二级分类:Other Quantitative Biology 其他定量生物学
分类描述:Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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英文摘要:
Ubiquitin, discovered less than 50 years ago, tags thousands of diseased proteins for destruction. It is small (only 76 amino acids), and is found unchanged in mammals, birds, fish and even worms. Key features of its functionality are identified here using critical point thermodynamic scaling theory. These include Fano interference between first- and second-order elements of globular surface shape transitions. Comparison with its closest relative, 76 amino acid Nedd8, shows that the latter lacks these features. A cracked elastic network model is proposed for the common target shared by many diseased proteins.
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PDF链接:
https://arxiv.org/pdf/1611.03818