培养细胞总数的自动调节

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摘要翻译：
根据普遍接受的地球上生命发展的概念，多细胞生物最初是由于相同的单细胞生物结合而随后发生功能分化的结果，或者是由于共生体结合而出现的结果，在共生体结合中已经存在某种简单的功能分离。然而，在这两种情况下，多细胞生物的祖先都是单细胞生物的群体。要把一定数量的单细胞生物作为一个集合体来对待，其成员之间必须有某种相互联系。机械连接的单细胞生物群体是较晚的，更高级的阶段；这里考虑单独生活的单细胞生物。特别是，这种相互联系必须从以上限制集合成员的总人数，因为这些人数的过度增加可能会扰乱集合成员之间的联系，直至其破坏的程度。此外，群体中成员数量过大可能导致其栖息地的营养耗尽。人们可以假定，单细胞生物之间的这种互连是进化发展起来的，是遗传固定的。我假设现代单细胞生物保持着这样一种调节其总数的能力。实验验证了这一假设的有效性，并给出了实验结果。
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英文标题：
《Autoregulation of the total number of cells in culture》
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作者：
A.A.Kozlov
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最新提交年份：
2003
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分类信息：

一级分类：Physics        物理学
二级分类：Biological Physics        生物物理学
分类描述：Molecular biophysics, cellular biophysics, neurological biophysics, membrane biophysics, single-molecule biophysics, ecological biophysics, quantum phenomena in biological systems (quantum biophysics), theoretical biophysics, molecular dynamics/modeling and simulation, game theory, biomechanics, bioinformatics, microorganisms, virology, evolution, biophysical methods.
分子生物物理、细胞生物物理、神经生物物理、膜生物物理、单分子生物物理、生态生物物理、生物系统中的量子现象（量子生物物理）、理论生物物理、分子动力学/建模与模拟、博弈论、生物力学、生物信息学、微生物、病毒学、进化论、生物物理方法。
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一级分类：Quantitative Biology        数量生物学
二级分类：Other Quantitative Biology        其他定量生物学
分类描述：Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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英文摘要：
  According to the universally accepted concept of the development of life on the Earth, multicellular organisms initially emerged as a result of either the union of identical unicellular organisms with the following functional differentiation, or the union of symbionts, in which there already was a certain simple functional separation. However, in either case the progenitors of multicellular organisms were ensembles, communities of unicellular organisms. For a certain number of unicellular organisms to be treated as an ensemble, there must be some interconnection between its members. Colonies of mechanically connected unicellular organisms were a later, more advanced stage; here, unicellular organisms living separately are considered. Such interconnection must, in particular, limit from above the total numbers of the members of the ensemble, because an excessive increase in these numbers could disturb the connections between members of the ensemble to the extent of its destruction. In addition, too large numbers of members in the ensemble could lead to nutrient depletion in its habitat. One can assume that such interconnection between unicellular organisms was evolutionarily developed and genetically fixed. I assumed that modern unicellular organisms retain such an ability to regulate their total numbers. The validity of this assumption was tested in experiments, whose results are presented in this paper.
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PDF链接：
https://arxiv.org/pdf/physics/0301072

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关键词：自动调节 Quantitative QUANTITATIV Destruction Game Theory 单细胞 集合 members either 功能