发布时间：2015-04-01 来源：人大经济论坛

制药工程论文范文 目 录 中文摘要 I 英文摘要 II 目录 1 绪论 1 1.1　凝胶 1 1.2 高分子可降解材料 1 1.3 研究内容 3 2 实验部分 4 2.1　实验试剂和仪器 4 2.1.1　实验试剂 4 2.1.2　实验仪器 4 2.2　实验方法 5 3 结果与讨论 9 3.1 原料的检测 9 3.2 CS-CMC温敏凝胶的形成 12 3.3 凝胶制备条件对凝胶形成的影响 13 3.4 CS-CMC凝胶的处方优化 15 3.5 凝胶性能测试 16 4 总结与展望 20 致谢 21 参考文献 22 摘要：本论文研究制备了能够在生理条件下发生相转化的壳聚糖-羧甲基纤维素凝胶。首先用酸度计法测得羧甲基纤维素钠的取代度、双突越滴定法测得壳聚糖的脱乙酰度，用乌氏粘度计测得羧甲基纤维素钠、壳聚糖的粘均分子量，然后通过物理共混技术制备得到互穿网络的壳聚糖-羧甲基纤维素水凝胶。通过对水凝胶制备条件的考察，优选出具有快速响应性的水凝胶，并对制得的凝胶进行了确证和性能测定，如红外光谱、溶胀度、透光率、相转变温度等。实验结果表明：当壳聚糖溶液pH=4.6，质量分数为1% 羧甲基纤维素钠溶液与等浓度壳聚糖溶液以0.8的体积比混合时，壳聚糖-羧甲基纤维素溶液在 41℃发生凝胶化，凝胶时间为1min。该凝胶在室温或低于室温时可保持液态，当温度达到体温时可快速发生凝胶化，是一种可供医疗使用的智能水凝胶。 关键词：壳聚糖；羧甲基纤维素钠；温敏性 Abstract: This thesis is to introduce the preparation of the chitosan-carboxymethyl cellulose (CS-CMC) hydrogel, which can occur the pHase transformation under pHysiological conditions. Firstly, the substitution degree of sodium carboxymethyl cellulose was measured by pH meter titration method, and the deacetylation degree of chitosan was measured by two abrupt titration method. The viscosity average molecular weights of sodium carboxymethyl cellulose and chitosan were determined by ubbelohde viscometer. And then the interpenetrating network hydrogel of chitosan-carboxymethyl cellulose (CS-CMC) was prepared by pHysical blending technology. The fast response hydrogel was obtained after the preparation condition study. Finally the characteristics identification and performance measurement of the obtained gel were carried out, such as infrared spectroscopy, swelling ratio, transmittance, pHase transition temperature, and so on. The results show that when the pH of CS solution reaches 4.6, 1% CMC solution mixed with equal concentrations of CS solution in the volume ratio of 0.8, the solution gelled at 41 ℃, the gel time was less than 1min. This hydrogel can be kept in the liquid at room temperature or below room temperature, while when the temperature reaches body temperature, it can quickly gelled, This hydrogel is smart and can be used in medical treatment. Key words: Chitosan; Carboxymethyl Cellulose; thermo-sensitive