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Abstract: Methyl-2,3-O-isopropylidene-¦Â-D-ribofuranoside was prepared from D-ribose protected by 2,2-dimethoxypropane. Methyl-2,3-O-isopropylidene-5-o-trifluoromethanesulfonyl -¦Â-D-ribofuranoside glucoside was synthesized from methyl-2,3-o-isopropylidene-¦Â-D- ribofuranoside and TSCl. Then Methyl-2,3-o-isopropylidene-5-o-trifluoromethanesulfonyl-¦Â- D-ribofuranoside glucoside was reduced by NaBH4 to get methyl -2,3-O- isopropylidene-5- deaeration - beta -D- ribofuranose glucoside. Through the optimization and improvement of original process , this reaction is simple, duplicates well, reaction time is short, preceeds smothly, and the product is easy to purify, has the wided application in the industry.
Keywords£ºD- ribose; methyl; acetylize; furan ribofuranose