[定量生物学] 基于等温约束环扩展的DNA电路 放大作用 [推广有奖]

摘要翻译：
本文首次介绍了等温约束环延伸DNA扩增(ICLEDA)技术，它是一种新的扩增技术，结合了滚圈扩增(RCA)和链置换扩增(SDA)的优点。然后，我们用形式语言的理论对这一过程进行了形式化描述，并在此基础上说明了如何管理OR、and和GATES。然后我们解释如何引入否定，这使我们能够证明，原则上，使用ICLEDA实现DNA链上任何布尔函数的计算是可能的。
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英文标题：
《DNA Circuits Based on Isothermal Constrained Loop Extension DNA
  Amplification》
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作者：
Maurice Margenstern and Pascal Mayer and Sergey Verlan
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最新提交年份：
2011
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分类信息：

一级分类：Computer Science        计算机科学
二级分类：Emerging Technologies        新兴技术
分类描述：Covers approaches to information processing (computing, communication, sensing) and bio-chemical analysis based on alternatives to silicon CMOS-based technologies, such as nanoscale electronic, photonic, spin-based, superconducting, mechanical, bio-chemical and quantum technologies (this list is not exclusive). Topics of interest include (1) building blocks for emerging technologies, their scalability and adoption in larger systems, including integration with traditional technologies, (2) modeling, design and optimization of novel devices and systems, (3) models of computation, algorithm design and programming for emerging technologies.
涵盖基于硅CMOS技术替代品的信息处理（计算、通信、传感）和生物化学分析方法，如纳米级电子、光子、自旋、超导、机械、生物化学和量子技术（此列表不是唯一的）。感兴趣的主题包括：（1）新兴技术的构建块、其可伸缩性和在大型系统中的采用，包括与传统技术的集成；（2）新型设备和系统的建模、设计和优化；（3）新兴技术的计算模型、算法设计和编程。
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一级分类：Quantitative Biology        数量生物学
二级分类：Other Quantitative Biology        其他定量生物学
分类描述：Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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英文摘要：
  In this paper, we first describe the isothermal constrained loop extension DNA amplification (ICLEDA), which is a new variant of amplification combining the advantages of rolling circle amplification (RCA) and of strand displacement amplification (SDA). Then, we formalize this process in terms of the theory of formal languages and show, on the basis of this formulation, how to manage OR and AND gates. We then explain how to introduce negation, which allows us to prove that, in principle, it is possible to implement the computation of any boolean function on DNA strands using ICLEDA.
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PDF链接：
https://arxiv.org/pdf/1105.1424