[定量生物学] 生物学中纯机械模型的挑战与最小化 需要一个“机制加X”框架 [推广有奖]

摘要翻译：
自从20世纪70年代分子生物学出现以来，力学模型已经成为该领域的教条，对任何学科的“真正”理解都等同于力学描述。这损害了生物医学科学，除了一些例外，在正常生物学和疾病生物学中，包括神经退行性疾病和癌症病理学中，可以说没有取得显着的新的理解壮举。我主张一种“机制加X”范式，在这种范式中，机械模型的主要要素，如等级和相关性，与法理原则，如一般操作规则和生成原则相结合。根据手头的问题和研究的性质，X可以从已证实的物理定律到推测的生物学概括，如细胞同步性的概念原理。我认为，“机制加X”的方法最终应该旨在使生物学研究走出经常遇到的机械论陷阱的僵局，并将生物学重新定位到它以前阐明世界基本真理的能力。
---
英文标题：
《The challenges of purely mechanistic models in biology and the minimum
  need for a 'mechanism-plus-X' framework》
---
作者：
Sepehr Ehsani
---
最新提交年份：
2019
---
分类信息：

一级分类：Quantitative Biology        数量生物学
二级分类：Other Quantitative Biology        其他定量生物学
分类描述：Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
--

---
英文摘要：
  Ever since the advent of molecular biology in the 1970s, mechanical models have become the dogma in the field, where a "true" understanding of any subject is equated to a mechanistic description. This has been to the detriment of the biomedical sciences, where, barring some exceptions, notable new feats of understanding have arguably not been achieved in normal and disease biology, including neurodegenerative disease and cancer pathobiology. I argue for a "mechanism-plus-X" paradigm, where mainstay elements of mechanistic models such as hierarchy and correlation are combined with nomological principles such as general operative rules and generative principles. Depending on the question at hand and the nature of the inquiry, X could range from proven physical laws to speculative biological generalizations, such as the notional principle of cellular synchrony. I argue that the "mechanism-plus-X" approach should ultimately aim to move biological inquiries out of the deadlock of oft-encountered mechanistic pitfalls and reposition biology to its former capacity of illuminating fundamental truths about the world.
---
PDF链接：
https://arxiv.org/pdf/1905.10916