发帖
雷达卡
摘要翻译：
老化被分析为适应性的自发丧失和脆弱性的增加，这是动态系统的特征。控制论定义了一个系统可以用来防止或修复干扰造成的损害的一般调节机制。根据必要变化规律，可以通过最大限度地增加缓冲能力、补偿作用的范围以及对哪种作用适用于哪种干扰的知识来控制干扰。这就提出了一种通过提高机体的适应能力来恢复机体活力的一般策略。缓冲可以通过提供充足的休息和大量的营养物质来优化：氨基酸、抗氧化剂、甲基供体、维生素、矿物质等。知识和作用范围可以通过使生物体接受尽可能多的挑战来扩大。这些挑战最好是简短的，以免耗尽资源和产生不可逆转的损害。然而，它们应该足够强烈和不可预测，以导致过度调动资源修复损伤，并刺激生物体建立更强的能力来应对未来的挑战。这使得它们能够克服进化在生物体修复过程中所产生的权衡和限制，以保存潜在的稀缺资源。这种强烈的、“恐怖的”压力源通过“噪音顺序”机制增强机体，这种机制通过使功能失调的结构受到强烈的、随机的变化而破坏它们。它们包括热和冷、体力消耗、暴露、伸展、振动、禁食、食物毒素、微生物、环境富集和心理挑战。
---
英文标题：
《Cybernetic Principles of Aging and Rejuvenation: the
buffering-challenging strategy for life extension》
---
作者：
Francis Heylighen
---
最新提交年份：
2014
---
分类信息：
一级分类：Quantitative Biology 数量生物学
二级分类：Other Quantitative Biology 其他定量生物学
分类描述：Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
--
一级分类：Physics 物理学
二级分类：Adaptation and Self-Organizing Systems 自适应和自组织系统
分类描述：Adaptation, self-organizing systems, statistical physics, fluctuating systems, stochastic processes, interacting particle systems, machine learning
自适应，自组织系统，统计物理，波动系统，随机过程，相互作用粒子系统，机器学习
--
---
英文摘要：
Aging is analyzed as the spontaneous loss of adaptivity and increase in fragility that characterizes dynamic systems. Cybernetics defines the general regulatory mechanisms that a system can use to prevent or repair the damage produced by disturbances. According to the law of requisite variety, disturbances can be held in check by maximizing buffering capacity, range of compensatory actions, and knowledge about which action to apply to which disturbance. This suggests a general strategy for rejuvenating the organism by increasing its capabilities of adaptation. Buffering can be optimized by providing sufficient rest together with plenty of nutrients: amino acids, antioxidants, methyl donors, vitamins, minerals, etc. Knowledge and the range of action can be extended by subjecting the organism to an as large as possible variety of challenges. These challenges are ideally brief so as not to deplete resources and produce irreversible damage. However, they should be sufficiently intense and unpredictable to induce an overshoot in the mobilization of resources for damage repair, and to stimulate the organism to build stronger capabilities for tackling future challenges. This allows them to override the trade-offs and limitations that evolution has built into the organism's repair processes in order to conserve potentially scarce resources. Such acute, "hormetic" stressors strengthen the organism in part via the "order from noise" mechanism that destroys dysfunctional structures by subjecting them to strong, random variations. They include heat and cold, physical exertion, exposure, stretching, vibration, fasting, food toxins, micro-organisms, environmental enrichment and psychological challenges.
---
PDF链接：
https://arxiv.org/pdf/1403.8135
京公网安备 11010802022788号
