摘要翻译:
我们提出了一个随机过程,其中分子输运是由一维底物上区域的不对称成核介导的。在生物物理应用中,如Holliday连接的定位和胶原酶的加工过程中,分子转运的轨道驱动机制出现。与水解三磷酸核苷酸并发生局部分子构象变化的分子马达相反,我们发现水解波在轨道上的不对称成核也可以导致附着粒子的定向运动。每个晶格位上的“水解”和“未水解”状态之间的不对称合作动力学产生移动的畴壁,推动位于轨道上的粒子。我们使用一种新的脉动框架有限段平均场理论来精确计算被驱动颗粒的稳态速度,并发现产生最大畴壁通量的参数状态,从而导致最佳颗粒漂移。
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英文标题:
《Brownian ratchets driven by asymmetric nucleation of hydrolysis waves》
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作者:
Amit Lakhanpal and Tom Chou
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最新提交年份:
2007
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分类信息:
一级分类:Physics 物理学
二级分类:Statistical Mechanics 统计力学
分类描述:Phase transitions, thermodynamics, field theory, non-equilibrium phenomena, renormalization group and scaling, integrable models, turbulence
相变,热力学,场论,非平衡现象,重整化群和标度,可积模型,湍流
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一级分类:Physics 物理学
二级分类:Soft Condensed Matter 软凝聚态物质
分类描述:Membranes, polymers, liquid crystals, glasses, colloids, granular matter
膜,聚合物,液晶,玻璃,胶体,颗粒物质
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英文摘要:
We propose a stochastic process wherein molecular transport is mediated by asymmetric nucleation of domains on a one-dimensional substrate. Track-driven mechanisms of molecular transport arise in biophysical applications such as Holliday junction positioning and collagenase processivity. In contrast to molecular motors that hydrolyze nucleotide triphosphates and undergo a local molecular conformational change, we show that asymmetric nucleation of hydrolysis waves on a track can also result in directed motion of an attached particle. Asymmetrically cooperative kinetics between ``hydrolyzed'' and ``unhydrolyzed'' states on each lattice site generate moving domain walls that push a particle sitting on the track. We use a novel fluctuating-frame, finite-segment mean field theory to accurately compute steady-state velocities of the driven particle and to discover parameter regimes which yield maximal domain wall flux, leading to optimal particle drift.
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PDF链接:
https://arxiv.org/pdf/705.2905