摘要翻译:
分子跨通道的运动对于理解细胞过程的机制至关重要。本文通过分析精确可解的离散随机模型来研究分子输运过程中相互作用的机理。结果表明,分子/通道相互作用的强度和空间分布对粒子电流有很强的影响。我们的分析表明,当结合位点靠近孔隙的入口或出口时,达到最优的传输。此外,本文还研究了分子间相互作用的作用,认为在一定的最佳相互作用强度下,可以观察到通量的增加。讨论了这些现象产生的机理。
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英文标题:
《How Interactions Control Molecular Transport in Channels》
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作者:
Anatoly B. Kolomeisky and Karthik Uppulury
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最新提交年份:
2010
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分类信息:
一级分类:Physics 物理学
二级分类:Soft Condensed Matter 软凝聚态物质
分类描述:Membranes, polymers, liquid crystals, glasses, colloids, granular matter
膜,聚合物,液晶,玻璃,胶体,颗粒物质
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一级分类:Quantitative Biology 数量生物学
二级分类:Other Quantitative Biology 其他定量生物学
分类描述:Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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英文摘要:
The motion of molecules across channels is critically important for understanding mechanisms of cellular processes. Here we investigate the mechanism of interactions in the molecular transport by analyzing exactly solvable discrete stochastic models. It is shown that the strength and spatial distribution of molecule/channel interactions can strongly modify the particle current. Our analysis indicates that the most optimal transport is achieved when the binding sites are near the entrance or exit of the pore. In addition, the role of intermolecular interactions is studied, and it is argued that an increase in flux can be observed for some optimal interaction strength. The mechanism of these phenomena is discussed.
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PDF链接:
https://arxiv.org/pdf/1003.2600