摘要翻译:
随着全球人口老龄化,人们对长寿和提高晚年生活质量越来越感兴趣。然而,研究衰老--身体机能的下降--既昂贵又耗时。尽管研究成功地使模式生物活得更长,但仍然没有任何可行的方法来延缓人类的衰老。随着太空旅行,科学家们无法知道到达月球需要什么。他们不得不从理论和短程测试中推断出来。也许随着年龄的增长,我们需要一个类似的月球拍摄哲学。尽管“射杀”可能意味着医学,但也许我们需要超越生物干预来思考。就像月球一样,我们似乎离增加人类健康跨度(一个人生命的健康期)或寿命(一个人的寿命)的可证明的疗法还有很长的路要走。因此,本审查侧重于激进的建议。我们希望它能激发关于我们可以考虑做与正在进行的衰老研究有显著不同的事情的讨论。
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英文标题:
《Moonshots for aging》
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作者:
Sandeep Kumar, Timothy R. Peterson
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最新提交年份:
2019
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分类信息:
一级分类:Quantitative Biology 数量生物学
二级分类:Other Quantitative Biology 其他定量生物学
分类描述:Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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英文摘要:
As the global population ages, there is increased interest in living longer and improving one's quality of life in later years. However, studying aging - the decline in body function - is expensive and time-consuming. And despite research success to make model organisms live longer, there still aren't really any feasible solutions for delaying aging in humans. With space travel, scientists couldn't know what it would take to get to the moon. They had to extrapolate from theory and shorter-range tests. Perhaps with aging, we need a similar moonshot philosophy. And though "shot" might imply medicine, perhaps we need to think beyond biological interventions. Like the moon, we seem a long way away from provable therapies to increase human healthspan (the healthy period of one's life) or lifespan (how long one lives). This review therefore focuses on radical proposals. We hope it might stimulate discussion on what we might consider doing significantly differently than ongoing aging research.
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PDF链接:
https://arxiv.org/pdf/1901.04053