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摘要翻译：
DNA微阵列实验是一种成熟的实验技术，旨在了解基因在某些生物过程中的功能。功能基因组学研究中最常见的实验之一是比较两组微阵列数据，以确定哪些基因差异表达。在这篇论文中，我们提出了一种方法来估计这类实验中差异表达基因的比例。我们在一个仿真研究中研究了我们的方法的性能，并将其与其他标准方法进行了比较。最后，我们用两个小鼠毒理学实验的真实数据对方法进行了比较。
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英文标题：
《Estimating the proportion of differentially expressed genes in
comparative DNA microarray experiments》
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作者：
Javier Cabrera, Ching-Ray Yu
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最新提交年份：
2007
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分类信息：
一级分类：Statistics 统计学
二级分类：Methodology 方法论
分类描述：Design, Surveys, Model Selection, Multiple Testing, Multivariate Methods, Signal and Image Processing, Time Series, Smoothing, Spatial Statistics, Survival Analysis, Nonparametric and Semiparametric Methods
设计，调查，模型选择，多重检验，多元方法，信号和图像处理，时间序列，平滑，空间统计，生存分析，非参数和半参数方法
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英文摘要：
DNA microarray experiments, a well-established experimental technique, aim at understanding the function of genes in some biological processes. One of the most common experiments in functional genomics research is to compare two groups of microarray data to determine which genes are differentially expressed. In this paper, we propose a methodology to estimate the proportion of differentially expressed genes in such experiments. We study the performance of our method in a simulation study where we compare it to other standard methods. Finally we compare the methods in real data from two toxicology experiments with mice.
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PDF链接：
https://arxiv.org/pdf/708.0968
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