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摘要翻译：
利用离散和连续的随机模型研究了电压驱动的非均匀带电聚合物通过纳米孔的易位。作为电荷分布对易位影响的一个简化说明，我们考虑了在电荷与孔之间存在和不存在相互作用的情况下，具有单个带电位的聚合物的易位。我们发现，在没有孔-聚合物相互作用的情况下，最小化易位时间的电荷位置由易位熵代价决定，对于棒状聚合物，最佳电荷位置位于链的中点，对于理想链，最佳电荷位置位于链的前端。孔道-电荷相互作用的吸引性或排斥性使电荷的最佳位置分别向链的尾端和前端移动。此外，我们的结果表明，相对于通过惰性孔的易位，电荷与孔之间强烈的吸引或排斥作用延长了易位时间。我们推广了我们的结果，以适应聚合物上多个带电位的存在。我们的结果提供了深入了解电荷不均匀性对蛋白质通过生物膜转运的影响。
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英文标题：
《Effect of charge distribution on the translocation of an inhomogeneously
charged polymer through a nanopore》
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作者：
Aruna Mohan, Anatoly B. Kolomeisky and Matteo Pasquali
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最新提交年份：
2007
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分类信息：
一级分类：Physics 物理学
二级分类：Soft Condensed Matter 软凝聚态物质
分类描述：Membranes, polymers, liquid crystals, glasses, colloids, granular matter
膜，聚合物，液晶，玻璃，胶体，颗粒物质
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一级分类：Physics 物理学
二级分类：Statistical Mechanics 统计力学
分类描述：Phase transitions, thermodynamics, field theory, non-equilibrium phenomena, renormalization group and scaling, integrable models, turbulence
相变，热力学，场论，非平衡现象，重整化群和标度，可积模型，湍流
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英文摘要：
We investigate the voltage-driven translocation of an inhomogeneously charged polymer through a nanopore by utilizing discrete and continuous stochastic models. As a simplified illustration of the effect of charge distribution on translocation, we consider the translocation of a polymer with a single charged site in the presence and absence of interactions between the charge and the pore. We find that the position of the charge that minimizes the translocation time in the absence of pore--polymer interactions is determined by the entropic cost of translocation, with the optimum charge position being at the midpoint of the chain for a rodlike polymer and close to the leading chain end for an ideal chain. The presence of attractive or repulsive pore--charge interactions yields a shift in the optimum charge position towards the trailing end and the leading end of the chain, respectively. Moreover, our results show that strong attractive or repulsive interactions between the charge and the pore lengthen the translocation time relative to translocation through an inert pore. We generalize our results to accommodate the presence of multiple charged sites on the polymer. Our results provide insight into the effect of charge inhomogeneity on protein translocation through biological membranes.
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PDF链接：
https://arxiv.org/pdf/711.0228
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