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摘要翻译：
细胞骨架是ATP水解导致“活性”介质失衡的一个显著例子。这种活性最近被证明对细胞介质的机械和流变学性质及其运输性质有惊人的影响：一种普通的示踪粒子像在标准平衡介质中一样自由扩散，但也以随机的相互作用时间间歇性地与运动蛋白结合，运动蛋白沿着细胞骨架丝进行活跃的弹道漂移。在此，我们首次提出了一个在活性介质中迁移限制反应的分析模型，并定量地说明了活性迁移如何能提高像囊泡这样足够大的示踪剂的反应活性。我们解析地导出了优化反应速率的与运动蛋白的平均相互作用时间，并揭示了最优构型的显著普适性。我们讨论了为什么主动转运可能在各种生物学例子中是有益的：细胞骨架、膜和片层，以及像轴突这样的管状结构。
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英文标题：
《Enhanced reaction kinetics in biological cells》
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作者：
C. Loverdo, O. Benichou, M. Moreau, R. Voituriez
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最新提交年份：
2008
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分类信息：
一级分类：Physics 物理学
二级分类：Statistical Mechanics 统计力学
分类描述：Phase transitions, thermodynamics, field theory, non-equilibrium phenomena, renormalization group and scaling, integrable models, turbulence
相变，热力学，场论，非平衡现象，重整化群和标度，可积模型，湍流
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一级分类：Quantitative Biology 数量生物学
二级分类：Cell Behavior 细胞行为
分类描述：Cell-cell signaling and interaction; morphogenesis and development; apoptosis; bacterial conjugation; viral-host interaction; immunology
细胞-细胞信号传导及相互作用；形态发生和发育；细胞凋亡；细菌接合；病毒-宿主相互作用；免疫学
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一级分类：Quantitative Biology 数量生物学
二级分类：Quantitative Methods 定量方法
分类描述：All experimental, numerical, statistical and mathematical contributions of value to biology
对生物学价值的所有实验、数值、统计和数学贡献
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英文摘要：
The cell cytoskeleton is a striking example of "active" medium driven out-of-equilibrium by ATP hydrolysis. Such activity has been shown recently to have a spectacular impact on the mechanical and rheological properties of the cellular medium, as well as on its transport properties : a generic tracer particle freely diffuses as in a standard equilibrium medium, but also intermittently binds with random interaction times to motor proteins, which perform active ballistic excursions along cytoskeletal filaments. Here, we propose for the first time an analytical model of transport limited reactions in active media, and show quantitatively how active transport can enhance reactivity for large enough tracers like vesicles. We derive analytically the average interaction time with motor proteins which optimizes the reaction rate, and reveal remarkable universal features of the optimal configuration. We discuss why active transport may be beneficial in various biological examples: cell cytoskeleton, membranes and lamellipodia, and tubular structures like axons.
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PDF链接：
https://arxiv.org/pdf/802.1493
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