摘要翻译:
我们提出了一个在大肠杆菌中葡萄糖-乳糖双向生长的数学模型,包括乳糖操纵子的postive和负调控机制以及诱导子排斥。为了验证该模型,我们首先计算了仅含乳糖营养物的β-半乳糖苷酶的时间演化,并将数值结果与实验数据进行了比较。其次,我们比较了葡萄糖-乳糖双辅酶生长的计算细胞生物量和一个特定大肠杆菌MG1655双辅酶生长的实验光密度。对于这两种情况,用该模型进行的数值计算与这两个实验的数据吻合得很好。本文还研究了一种野生型大肠杆菌的双向生长模式。
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英文标题:
《Dynamics of glucose-lactose diauxic growth in E. coli》
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作者:
Zhao Lu and Michael A Lee
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最新提交年份:
2011
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分类信息:
一级分类:Quantitative Biology 数量生物学
二级分类:Other Quantitative Biology 其他定量生物学
分类描述:Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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一级分类:Quantitative Biology 数量生物学
二级分类:Cell Behavior 细胞行为
分类描述:Cell-cell signaling and interaction; morphogenesis and development; apoptosis; bacterial conjugation; viral-host interaction; immunology
细胞-细胞信号传导及相互作用;形态发生和发育;细胞凋亡;细菌接合;病毒-宿主相互作用;免疫学
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英文摘要:
We present a mathematical model of glucose-lactose diauxic growth in Escherichia coli including both the postive and negative regulation mechanisms of the lactose operon as well as the inducer exclusion. To validate this model, we first calculated the time evolution of beta-galactosidase for only the lactose nutrient and compared the numerical results with experimental data. Second, we compared the calculated cell biomass of the glucose-lactose diauxic growth with the experimental optical density of the diauxic growth for a particular E. coli MG 1655. For both cases, the numerical calculations from this model are in good agreement with these two experiments' data. The diauxic growth pattern of a wild type E. coli was also investigated.
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PDF链接:
https://arxiv.org/pdf/0708.1993