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摘要翻译：
Hodgkin-Huxley(HH)模型是一个强有力的模型，可以解释可兴奋细胞中刺突产生的不同方面。然而，HH模型是在1952年离子通道的真实结构尚不清楚的情况下提出的。众所周知，在许多离子通道蛋白质中，离子通过孔道的流动是由一个门控制的，该门包括离子通道内的一个所谓的选择性过滤器，该过滤器可以通过电相互作用来控制。选择性过滤器被认为负责特定离子的选择和快速传导穿过可兴奋细胞膜。分子的其他部分（通常较大），如孔域门，控制离子进入通道蛋白。实际上，离子通道的栅极有两种：外栅极，即电压敏感栅极，内栅极，即选择性过滤栅极(SFG)。由于SFG的尺寸较小，其量子效应对离子通道的运行起着重要作用。在这里，我们检查一个广义的HH模型中的参数，看看是否有任何参数影响尖峰的产生。我们的结果表明，Bernroider和Summhammer(BS)提出的半量子经典方程在不同条件下与HH方程有很强的一致性，在某些情况下甚至可以提供更好的解释。结果表明，BS模型对经典的HH模型有很大的改进作用。
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英文标题：
《Selectivity filter gate versus voltage-sensitive gate: A study of
quantum probabilities in the Hodgkin-Huxley equation》
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作者：
Narges Moradi, Felix Scholkmann, Vahid Salari
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最新提交年份：
2014
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分类信息：
一级分类：Quantitative Biology 数量生物学
二级分类：Other Quantitative Biology 其他定量生物学
分类描述：Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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英文摘要：
The Hodgkin-Huxley (HH) model is a powerful model to explain different aspects of spike generation in excitable cells. However, the HH model was proposed in 1952 when the real structure of the ion channel was unknown. It is now common knowledge that in many ion-channel proteins the flow of ions through the pore is governed by a gate, comprising a so-called selectivity filter inside the ion channel, which can be controlled by electrical interactions. The selectivity filter is believed to be responsible for the selection and fast conduction of particular ions across the membrane of an excitable cell. Other (generally larger) parts of the molecule such as the pore-domain gate control the access of ions to the channel protein. In fact, two types of gates are considered here for ion channels: the external gate, which is the voltage sensitive gate, and the internal gate which is the selectivity filter gate (SFG). Some quantum effects are to expected in the SFG due to its small dimensions, which may play an important role in the operation of an ion channel. Here, we examine parameters in a generalized model of HH to see whether any parameter affects the spike generation. Our results indicate that the previously suggested semi-quantum-classical equation proposed by Bernroider and Summhammer (BS) agrees strongly with the HH equation under different conditions and may even provide a better explanation in some cases. We conclude that the BS model can refine the classical HH model substantially.
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PDF链接：
https://arxiv.org/pdf/1410.1134
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