摘要翻译:
DNA的电子性质被认为在生物体内的许多现象中起着至关重要的作用,例如通过碱基切除修复(BER)糖苷酶定位DNA损伤,通过检测氧化损伤调节p53等抑癌基因。然而,即使经过十多年的努力,在纳米尺度上对电荷通过DNA分子迁移的可重复性测量和建模仍然是一个具有挑战性和争议性的课题。在这里,我们通过分析来自各种医学数据库的162个疾病相关基因,总共观察到近20,000个致病突变,表明与所有可能的突变组相比,观察到的突变组的电子性质有显著差异。我们的结果对DNA的电子性质在细胞过程中的作用有一定的意义,并提示了预测、早期诊断和检测突变热点的可能性。
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英文标题:
《The interplay of mutations and electronic properties in disease-related
genes》
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作者:
Chi-Tin Shih, Stephen A. Wells, Ching-Ling Hsu, Yun-Yin Cheng, Rudolf
A. R\"omer
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最新提交年份:
2011
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分类信息:
一级分类:Quantitative Biology 数量生物学
二级分类:Other Quantitative Biology 其他定量生物学
分类描述:Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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一级分类:Physics 物理学
二级分类:Biological Physics 生物物理学
分类描述:Molecular biophysics, cellular biophysics, neurological biophysics, membrane biophysics, single-molecule biophysics, ecological biophysics, quantum phenomena in biological systems (quantum biophysics), theoretical biophysics, molecular dynamics/modeling and simulation, game theory, biomechanics, bioinformatics, microorganisms, virology, evolution, biophysical methods.
分子生物物理、细胞生物物理、神经生物物理、膜生物物理、单分子生物物理、生态生物物理、生物系统中的量子现象(量子生物物理)、理论生物物理、分子动力学/建模与模拟、博弈论、生物力学、生物信息学、微生物、病毒学、进化论、生物物理方法。
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英文摘要:
Electronic properties of DNA are believed to play a crucial role in many phenomena in living organisms, for example the location of DNA lesions by base excision repair (BER) glycosylases and the regulation of tumor-suppressor genes such as p53 by detection of oxidative damage. However, the reproducible measurement and modelling of charge migration through DNA molecules at the nanometer scale remains a challenging and controversial subject even after more than a decade of intense efforts. Here we show, by analysing 162 disease-related genes from a variety of medical databases with a total of almost 20,000 observed pathogenic mutations, a significant difference in the electronic properties of the population of observed mutations compared to the set of all possible mutations. Our results have implications for the role of the electronic properties of DNA in cellular processes, and hint at the possibility of prediction, early diagnosis and detection of mutation hotspots.
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PDF链接:
https://arxiv.org/pdf/1109.5979