基于本体的COVID-19表型标注与分析

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摘要翻译：
新冠肺炎疫情给全球不同领土的公共卫生造成了一场难以预料的毁灭性灾难。常见的表型包括发热、咳嗽、呼吸急促和寒战。随着更多的病例被调查，其他临床表型逐渐被认识，例如嗅觉丧失和味觉丧失。与出院或治愈患者相比，重症或死亡患者往往有一种或多种共病，如高血压、糖尿病、心血管疾病等。本研究从70篇文章中系统收集分析了COVID-19相关临床表型。根据人类表型本体论(HPO)将常见的17种表型分为不同的类群。根据HP分类，我们系统分析了患者的3种神经表型（嗅觉丧失、味觉丧失和头痛）和4种腹部表型（恶心、呕吐、腹痛和腹泻），发现欧洲和美国患者的神经表型和腹部表型高于亚洲患者。共发现23种共病在新冠肺炎患者中普遍存在。与没有这些共病的患者相比，糖尿病和肾衰竭等共病患者的预后更差。
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英文标题：
《Ontology-based annotation and analysis of COVID-19 phenotypes》
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作者：
Yang Wang, Fengwei Zhang, Hong Yu, Xianwei Ye, Yongqun He
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最新提交年份：
2020
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分类信息：

一级分类：Quantitative Biology        数量生物学
二级分类：Other Quantitative Biology        其他定量生物学
分类描述：Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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英文摘要：
  The epidemic of COVID-19 has caused an unpredictable and devastated disaster to the public health in different territories around the world. Common phenotypes include fever, cough, shortness of breath, and chills. With more cases investigated, other clinical phenotypes are gradually recognized, for example, loss of smell, and loss of tastes. Compared with discharged or cured patients, severe or died patients often have one or more comorbidities, such as hypertension, diabetes, and cardiovascular disease. In this study, we systematically collected and analyzed COVID-19-related clinical phenotypes from 70 articles. The commonly occurring 17 phenotypes were classified into different groups based on the Human Phenotype Ontology (HPO). Based on the HP classification, we systematically analyze three nervous phenotypes (loss of smell, loss of taste, and headache) and four abdominal phenotypes (nausea, vomiting, abdominal pain, and diarrhea) identified in patients, and found that patients from Europe and USA turned to have higher nervous phenotypes and abdominal phenotypes than patients from Asia. A total of 23 comorbidities were found to commonly exist among COVID-19 patients. Patients with these comorbidities such as diabetes and kidney failure had worse outcomes compared with those without these comorbidities.
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PDF链接：
https://arxiv.org/pdf/2008.02241

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关键词：OVID Quantitative QUANTITATIV Systematic recognized 味觉 新冠 based comorbidities 临床