摘要翻译:
我们研究了随时间变化的噪声对发育中胚胎形态发生梯度形状的影响。利用摄动理论计算了一个鲁棒梯度形成的简单反应扩散模型对确定性行为的偏差,并通过数值模拟验证了结果。结果表明,这种偏差会破坏足够高噪声水平下的鲁棒性,并讨论了这些发现对更复杂的梯度成形路径模型的影响。
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英文标题:
《Morphogen Gradient from a Noisy Source》
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作者:
Jeremy L. England, John Cardy
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最新提交年份:
2005
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分类信息:
一级分类:Quantitative Biology 数量生物学
二级分类:Tissues and Organs 组织器官
分类描述:Blood flow in vessels, biomechanics of bones, electrical waves, endocrine system, tumor growth
血管内血流,骨骼生物力学,电波,内分泌系统,肿瘤生长
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一级分类:Physics 物理学
二级分类:Other Condensed Matter 其他凝聚态物质
分类描述:Work in condensed matter that does not fit into the other cond-mat classifications
在不适合其他cond-mat分类的凝聚态物质中工作
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一级分类:Quantitative Biology 数量生物学
二级分类:Molecular Networks 分子网络
分类描述:Gene regulation, signal transduction, proteomics, metabolomics, gene and enzymatic networks
基因调控、信号转导、蛋白质组学、代谢组学、基因和酶网络
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一级分类:Quantitative Biology 数量生物学
二级分类:Other Quantitative Biology 其他定量生物学
分类描述:Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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英文摘要:
We investigate the effect of time-dependent noise on the shape of a morphogen gradient in a developing embryo. Perturbation theory is used to calculate the deviations from deterministic behavior in a simple reaction-diffusion model of robust gradient formation, and the results are confirmed by numerical simulation. It is shown that such deviations can disrupt robustness for sufficiently high noise levels, and the implications of these findings for more complex models of gradient-shaping pathways are discussed.
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PDF链接:
https://arxiv.org/pdf/q-bio/0502036