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摘要翻译：
许多新出现的病原体感染多个宿主物种，多宿主病原体在不同宿主物种中可能有很大不同的动态。这项研究探讨了病原体复制率和免疫系统(IS)反应时间如何受到宿主身体大小的限制。常微分方程模型表明，病原菌的复制率随宿主体大小而下降，而应答率随宿主体大小而不变。利用基于Agent的模型(ABM)研究了两种能够解释is响应速率尺度不变性的is体系结构模型。提出了一个阶段结构的混合模型，通过分别在感染的初始阶段和后期使用它们，在ABM的详细表示和ODE的计算可处理性之间取得平衡。
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英文标题：
《A Hybrid Agent Based and Differential Equation Model of Body Size
Effects on Pathogen Replication and Immune System Response》
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作者：
Soumya Banerjee, Melanie Moses
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最新提交年份：
2009
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分类信息：
一级分类：Quantitative Biology 数量生物学
二级分类：Other Quantitative Biology 其他定量生物学
分类描述：Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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英文摘要：
Many emerging pathogens infect multiple host species, and multi-host pathogens may have very different dynamics in different host species. This research addresses how pathogen replication rates and Immune System (IS) response times are constrained by host body size. An Ordinary Differential Equation (ODE) model is used to show that pathogen replication rates decline with host body size but IS response rates remain invariant with body size. An Agent-Based Model (ABM) is used to investigate two models of IS architecture that could explain scale invariance of IS response rates. A stage structured hybrid model is proposed that strikes a balance between the detailed representation of an ABM and computational tractability of an ODE, by using them in the initial and latter stages of an infection, respectively.
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PDF链接：
https://arxiv.org/pdf/0910.3146
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