摘要翻译:
免疫系统衰老即免疫衰老的研究是一个较新的研究课题。它涉及了解免疫降解的过程,表明功能丧失的迹象,可能导致死亡。尽管不可能预防免疫衰老,但了解其原因有很大的好处,这可能有助于扭转所造成的一些损害,从而提高预期寿命。影响免疫衰老过程的主要因素之一是个体中幼稚T细胞的数量和表型变化。本研究综述了免疫衰老,提出了系统动力学模型的过程涉及到维持幼稚T细胞库,并给出了一些初步结果。
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英文标题:
《System Dynamics Modelling of the Processes Involving the Maintenance of
the Naive T Cell Repertoire》
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作者:
Grazziela P. Figueredo, Uwe Aickelin, Amanda Whitbrook
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最新提交年份:
2010
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分类信息:
一级分类:Computer Science 计算机科学
二级分类:Artificial Intelligence 人工智能
分类描述:Covers all areas of AI except Vision, Robotics, Machine Learning, Multiagent Systems, and Computation and Language (Natural Language Processing), which have separate subject areas. In particular, includes Expert Systems, Theorem Proving (although this may overlap with Logic in Computer Science), Knowledge Representation, Planning, and Uncertainty in AI. Roughly includes material in ACM Subject Classes I.2.0, I.2.1, I.2.3, I.2.4, I.2.8, and I.2.11.
涵盖了人工智能的所有领域,除了视觉、机器人、机器学习、多智能体系统以及计算和语言(自然语言处理),这些领域有独立的学科领域。特别地,包括专家系统,定理证明(尽管这可能与计算机科学中的逻辑重叠),知识表示,规划,和人工智能中的不确定性。大致包括ACM学科类I.2.0、I.2.1、I.2.3、I.2.4、I.2.8和I.2.11中的材料。
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一级分类:Quantitative Biology 数量生物学
二级分类:Cell Behavior 细胞行为
分类描述:Cell-cell signaling and interaction; morphogenesis and development; apoptosis; bacterial conjugation; viral-host interaction; immunology
细胞-细胞信号传导及相互作用;形态发生和发育;细胞凋亡;细菌接合;病毒-宿主相互作用;免疫学
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英文摘要:
The study of immune system aging, i.e. immunosenescence, is a relatively new research topic. It deals with understanding the processes of immunodegradation that indicate signs of functionality loss possibly leading to death. Even though it is not possible to prevent immunosenescence, there is great benefit in comprehending its causes, which may help to reverse some of the damage done and thus improve life expectancy. One of the main factors influencing the process of immunosenescence is the number and phenotypical variety of naive T cells in an individual. This work presents a review of immunosenescence, proposes system dynamics modelling of the processes involving the maintenance of the naive T cell repertoire and presents some preliminary results.
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PDF链接:
https://arxiv.org/pdf/1004.5215