发帖
雷达卡
摘要翻译：
我们研究了用于细胞建模的催化反应模型。反应动力学是通过不同种类分子的能量按随机独立分布来定义的。相关的统计物理模型有三个阶段，这三个阶段在动力学中出现：快动力学阶段、慢动力学阶段和超慢动力学阶段。我们发现的现象是一个比较笼统的现象，不依赖于模型的细节。我们假设这些阶段（玻璃度）之间的转变与癌症有关。细胞关键方面（基因调控、蛋白质相互作用、代谢网络）之间进程速度的不平衡导致这些关键方面之间微调的改变，影响细胞的逻辑并引发癌症。癌症很可能是由于代谢反应的增加和放松引起的阶段变化。
---
英文标题：
《The three different phases in the dynamics of chemical reaction networks
and their relationship to cancer》
---
作者：
David B. Saakian, Laurent Schwartz
---
最新提交年份：
2012
---
分类信息：
一级分类：Quantitative Biology 数量生物学
二级分类：Other Quantitative Biology 其他定量生物学
分类描述：Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
--
一级分类：Physics 物理学
二级分类：Soft Condensed Matter 软凝聚态物质
分类描述：Membranes, polymers, liquid crystals, glasses, colloids, granular matter
膜，聚合物，液晶，玻璃，胶体，颗粒物质
--
---
英文摘要：
We investigate the catalytic reactions model used in cell modeling. The reaction kinetic is defined through the energies of different species of molecules following random independent distribution. The related statistical physics model has three phases and these three phases emerged in the dynamics: fast dynamics phase, slow dynamic phase and ultra-slow dynamic phase. The phenomenon we found is a rather general, does not depend on the details of the model. We assume as a hypothesis that the transition between these phases (glassiness degrees) is related to cancer. The imbalance in the rate of processes between key aspects of the cell (gene regulation, protein-protein interaction, metabolical networks) creates a change in the fine tuning between these key aspects, affects the logics of the cell and initiates cancer. It is probable that cancer is a change of phase resulting from increased and deregulated metabolic reactions.
---
PDF链接：
https://arxiv.org/pdf/1212.0672
京公网安备 11010802022788号
