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摘要翻译：
CoV2019已经进化到比COV2003危险得多。实验表明，结构重排显著增强了CoV2019的活性。我们利用生物分子进化理论来识别增强病毒附着率的序列差异，从而识别出结构重排之前的新的感染第一阶段。我们发现了一小群突变，表明病毒有一个新的特征，促进了更强的病毒附着，并增强了传染性。人类冠状病毒感染的极其危险的动态是自组织网络进化到临界的一个戏剧性例子。它可能有利于一种非常成功的疫苗。所鉴定的突变可以用来实验检验目前的理论。
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英文标题：
《Synchronized Attachment and the Darwinian Evolution of Coronaviruses
CoV-1 and CoV-2》
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作者：
J. C. Phillips
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最新提交年份：
2020
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分类信息：
一级分类：Quantitative Biology 数量生物学
二级分类：Other Quantitative Biology 其他定量生物学
分类描述：Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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英文摘要：
CoV2019 has evolved to be much more dangerous than CoV2003. Experiments suggest that structural rearrangements dramatically enhance CoV2019 activity. We identify a new first stage of infection which precedes structural rearrangements by using biomolecular evolutionary theory to identify sequence differences enhancing viral attachment rates. We find a small cluster of mutations which show that CoV-2 has a new feature that promotes much stronger viral attachment and enhances contagiousness. The extremely dangerous dynamics of human coronavirus infection is a dramatic example of evolutionary approach of self-organized networks to criticality. It may favor a very successful vaccine. The identified mutations can be used to test the present theory experimentally.
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PDF链接：
https://arxiv.org/pdf/2008.12168
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