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英文文献：Determinants of Pharmaceutical Innovation: The Role of Technological Opportunities Revisited-药物创新的决定因素:重新审视技术机会的作用
英文文献作者：Bastian Rake
英文文献摘要：
Recent empirical contributions emphasize the importance of (potential) market size for the development of new pharmaceuticals. At the same time many scholars point out the importance of of scientific advances for the industry’s R&D activities. Against this background I analyze the relationship between (potential) market size, technological opportunities, and the number of new pharmaceuticals in the United States. Technological opportunities are operationalized as growth rates of the relevant knowledge stock as proposed by Andersen (1999, 1998). I analyze a unique dataset by using an “entry stock” Poisson quasi-maximum likelihood estimator. The results reveal a rather robust and significantly positive response of the number of new pharmaceuticals, i.e., new molecular entities or new drug approvals, to market size and technological opportunities.
最近的实证贡献强调了(潜在的)市场规模对于新药物开发的重要性。与此同时，许多学者指出了科学进步对产业研发活动的重要性。在此背景下，我分析了(潜在的)市场规模，技术机会和美国新药品数量之间的关系。正如Andersen(1999,1998)所提出的，技术机会是以相关知识存量的增长率来运作的。我使用“输入股票”泊松拟极大似然估计分析一个独特的数据集。结果显示，新药物的数量，例如，新的分子实体或新药批准，对市场规模和技术机会相当强劲和显著的积极反应。
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