With simple algebra the copula density with normal marginal distributions simplifies to
$$
c(u, ~v, ~\rho) = \frac{1}{\sqrt{1 - \rho^2}} ~exp\bigg(\frac{1}{2 ~(1 ~-~ \rho^2)}~ \bigg( \frac{2~\rho~(x - \mu_1)~(y - \mu_2)}{\sigma_1 ~\sigma_2} ~-~ \rho^2 ~\bigg (\frac{{x ~-~ \mu_1}^2}{\sigma_1} ~+~ \frac{{y ~-~ \mu_2}^2}{\sigma_2}\bigg)\bigg ) \bigg ). $$
The product of the copula density above, the normal marginal of $logit(\pi_{i1}$) and $logit(\pi_{i2}$) form a bivariate normal distribution which characterize the model by [@Reitsma], [@Arends], [@Chu], and [@Rileyb], the so-called bivariate random-effects meta-analysis (BRMA) model, recommended as the appropriate method for meta-analysis of diagnostic accuracy studies.
Study level covariate information explaining heterogeneity is introduced through the parameters of the marginal and the copula as follows
$$\boldsymbol{\mu}_j = \textbf{X}_j\textbf{B}_j^{\top}. $$
$\boldsymbol{X}_j$ is a $n \times p$ matrix containing the covariates values for the mean sensitivity($j = 1$) and specificity($j = 2$). For simplicity, assume that $\boldsymbol{X}_1 = \boldsymbol{X}_2 = \boldsymbol{X}$. $\boldsymbol{B}_j^\top$ is a $p \times$ 1$ vector of regression parameters, and $p$ is the number of parameters.
By inverting the logit functions, we obtain
$$
\pi_{ij} = logit^{-1} (\mu_j + \varepsilon_{ij}).
$$




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