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摘要翻译：
肿瘤高度依赖葡萄糖作为能量生产的底物，通常不能分解其他燃料来源，如酮和脂肪酸。因此，剥夺葡萄糖的获取途径有可能饿死癌细胞并诱导凋亡。不幸的是，其他身体组织在正常情况下也依赖葡萄糖获得能量。然而，在人类饥饿（或在饮食诱导的酮生成环境中），身体“酮适应”，大多数组织的葡萄糖需求几乎降至零。例外情况包括中枢神经系统(CNS)和其他各种组织，它们对葡萄糖的需求量很小，但却是必需的。我们假设的治疗是以酮适应为前提的。然后，我们提出在给大脑葡萄糖的同时，通过抑制糖异生来诱导严重的低血糖。虽然严重低血糖通常会产生癫痫发作和昏迷等不良反应，但酮适应后是相对安全的。我们假设我们的治疗性低血糖治疗有可能迅速诱导肿瘤细胞坏死。
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英文标题：
《Starvation of Cancer via Induced Ketogenesis and Severe Hypoglycemia》
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作者：
Adam Kapelner and Matthew Vorsanger
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最新提交年份：
2014
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分类信息：
一级分类：Quantitative Biology 数量生物学
二级分类：Other Quantitative Biology 其他定量生物学
分类描述：Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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英文摘要：
Neoplasms are highly dependent on glucose as their substrate for energy production and are generally not able to catabolize other fuel sources such as ketones and fatty acids. Thus, removing access to glucose has the potential to starve cancer cells and induce apoptosis. Unfortunately, other body tissues are also dependent on glucose for energy under normal conditions. However, in human starvation (or in the setting of diet-induced ketogenesis), the body "keto-adapts" and glucose requirements of most tissues drop to almost nil. Exceptions include the central nervous system (CNS) and various other tissues which have a small but obligatory requirement of glucose. Our hypothesized treatment takes keto-adaptation as a prerequisite. We then propose the induction of severe hypoglycemia by depressing gluconeogenesis while administering glucose to the brain. Although severe hypoglycemia normally produces adverse effects such as seizure and coma, it is relatively safe following ketoadaptation. We hypothesize that our therapeutic hypoglycemia treatment has potential to rapidly induce tumor cell necrosis.
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PDF链接：
https://arxiv.org/pdf/1407.7622
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