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摘要翻译：
众所周知，心理情绪障碍可能伴随着人类社交能力的下降。研究表明，雄性小鼠在每天10次激动性相互作用中的反复社交失败分别导致了焦虑水平的发展和在高架加迷宫和分割试验中估计的交流减少。在社会互动测试中，失败的雄性小鼠对陌生伴侣的社交行为和探索活动显著降低。避免接近伴侣明显增加。在失败的雄性中，自我修饰行为的表现增加。慢性地西泮(0.5mg/kg，i.p.，2周）可显著降低高架加迷宫试验中的焦虑水平，改善隔膜试验中的交流。在社会交往测试中，安定完全恢复了社交能力和探索活动水平，减少了接近伴侣的回避行为。安定不影响自我美容示范。结果表明，导致雄性败选小鼠交流减少的主要因素是高水平的焦虑。讨论了被打败的老鼠的社会行为变化与人类自闭症症状之间的相似性。认为这种行为学方法可能有助于研究自闭症谱系障碍的分子机制，这种障碍是在长期的负面社会经验下发展起来的。
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英文标题：
《Anxiety as a Factor in the Development of Autistic Spectrum Symptoms: an
Experimental Study》
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作者：
I.L. Kovalenko, N.N. Kudryavtseva
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最新提交年份：
2010
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分类信息：
一级分类：Quantitative Biology 数量生物学
二级分类：Other Quantitative Biology 其他定量生物学
分类描述：Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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一级分类：Physics 物理学
二级分类：Medical Physics 医学物理学
分类描述：Radiation therapy. Radiation dosimetry. Biomedical imaging modelling. Reconstruction, processing, and analysis. Biomedical system modelling and analysis. Health physics. New imaging or therapy modalities.
放射治疗。辐射剂量学。生物医学成像建模。重建、处理和分析。生物医学系统建模与分析。健康物理学。新的成像或治疗方式。
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英文摘要：
It is well known that psychoemotional disorders may be accompanied by decreased sociability in humans. It has been shown that repeated social defeats in 10 daily agonistic interactions in male mice led to development of the expressed level of anxiety and to reduction of communication estimated in the elevated plus-maze and partition tests, respectively. In the social interactions test, sociable behavior toward unfamiliar partner and exploratory activity were dramatically decreased in defeated male mice. Avoidance of approaching partner was significantly increased. Demonstration of self-grooming behavior was increased in defeated males. Chronic diazepam treatment (0.5 mg/kg, i.p., 2 weeks) led to significant decrease of anxiety level estimated in the elevated plus maze test and to improvement of communication in the partition test. In the social interaction test diazepam completely restored the level of sociability and exploratory activity and reduced avoidance behavior of approaching partner. Diazepam did not affect self-grooming demonstration. It is concluded that main factor which provokes decrease in communication in defeated male mice is the high level of anxiety. Similarity between changes in social behavior in defeated mice and symptoms of autism in humans is discussed. It is supposed that this behavioral approach may be useful for studying the molecular mechanisms of autistic spectrum disorders, developing under chronic negative social experiences.
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PDF链接：
https://arxiv.org/pdf/1005.0228
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