发帖
雷达卡
摘要翻译：
癌症是由遗传变异的积累引起的。由于这种积累需要时间，大多数癌症的发病率被认为随着年龄的增长呈指数增长。然而，对年龄别发病率的仔细测量表明，许多癌症的年龄别发病率随着年龄的增长而上升到最大值，然后下降。年龄别发病率随年龄而下降是一种异常现象。理解这种异常应该会导致对肿瘤如何发展和生长有更好的理解。在这里，我导出了特定年龄的发病率的形状，表明它应该遵循威布尔分布的形状。测量表明，结肠癌的年龄别发病率确实遵循威布尔分布。这一分析导致了结肠癌在一般人群中存在两个亚人群：易感人群和免疫人群。结肠肿瘤只会发生在易感人群中。这一分析与疾病发展起源假说是一致的，并可推广到许多其他常见的癌症形式。
---
英文标题：
《The age specific incidence anomaly suggests that cancers originate
during development》
---
作者：
James P. Brody
---
最新提交年份：
2013
---
分类信息：
一级分类：Quantitative Biology 数量生物学
二级分类：Other Quantitative Biology 其他定量生物学
分类描述：Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
--
---
英文摘要：
Cancers are caused by the accumulation of genetic alterations. Since this accumulation takes time, the incidence of most cancers is thought to increase exponentially with age. However, careful measurements of the age-specific incidence shows that the specific incidence for many forms of cancer rises with age to a maximum, then decreases. This decrease in the age-specific incidence with age is an anomaly. Understanding this anomaly should lead to a better understanding of how tumors develop and grow. Here I derive the shape of the age-specific incidence, showing that it should follow the shape of a Weibull distribution. Measurements indicate that the age-specific incidence for colon cancer does indeed follow a Weibull distribution. This analysis leads to the interpretation that for colon cancer two sub-populations exist in the general population: a susceptible population and an immune population. Colon tumors will only occur in the susceptible population. This analysis is consistent with the developmental origins of disease hypothesis and generalizable to many other common forms of cancer.
---
PDF链接：
https://arxiv.org/pdf/1310.8619
京公网安备 11010802022788号
