摘要翻译:
肥胖和糖尿病的治疗仍然是一个挑战,这些疾病的生物学机制仍然没有完全理解。糖尿病和肥胖与心血管并发症的风险增加有关,迫切需要寻找新的治疗方法来治疗肥胖和糖尿病。目前有几种方法来治疗这些疾病。其中,化学解耦剂可以作为一种有效的治疗肥胖症的药物,但其危险的副作用限制了其在体内的应用。在此,我们提出了一个基于化学解偶联剂作用机理的新的理论模型:类热原素体系(TLS)。TLS可以在体内复制化学解耦剂的作用机制,但没有危险的副作用。
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英文标题:
《Can the light be used to treat obesity and diabetes?》
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作者:
R\'edoane Daoudi
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最新提交年份:
2018
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分类信息:
一级分类:Quantitative Biology 数量生物学
二级分类:Other Quantitative Biology 其他定量生物学
分类描述:Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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英文摘要:
The treatment of obesity and diabetes remains a challenge and the biological mechanisms of these diseases are still not fully understood. Diabetes and obesity are associated with increased risk of the development of cardiovascular complications and there is an urgent need to find novel therapeutic approaches for treating obesity and diabetes. Currently there are several approaches to treat these diseases. Among them chemical uncouplers could be used as an effective treatment for obesity but the dangerous side effects of these compounds has limited their use in vivo. Here we propose a novel theoretical model based on the mechanism of action of chemical uncouplers: the thermogenin-like system (TLS). The TLS may be used in vivo to reproduce the mechanism of action of chemical uncouplers but without their dangerous side effects.
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PDF链接:
https://arxiv.org/pdf/1804.04500