高通量强度衍射层析成像 显微镜

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摘要翻译：
我们演示了一种无运动强度衍射层析成像技术，它能够从弱散射样品的仅强度测量中直接反演三维相位和吸收。我们导出了一个新的线性正演模型，具有分段相位和吸收传递函数，使用角度照明。这种新的框架便于灵活有效的数据采集，使得光照角度可以任意采样。该重建算法使用鲁棒的、计算和存储效率高的切片反卷积来实现三维合成孔径，以达到非相干极限的分辨率。我们用具有稀疏三维结构和密集细胞簇的厚生物样本演示了我们的技术。我们进一步研究了我们的技术在成像强散射样品时的局限性。利用一个由相位和吸收分辨率叠加目标组成的三维样品评估了成像性能和多次散射的影响。该计算显微系统直接建立在一个标准的商用显微镜上，带有一个简单的LED阵列光源附加件，通过利用无处不在的显微平台，以最小的硬件修改，具有广泛的应用前景。
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英文标题：
《High-throughput intensity diffraction tomography with a computational
  microscope》
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作者：
Ruilong Ling, Waleed Tahir, Hsing-Ying Lin, Hakho Lee, Lei Tian
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最新提交年份：
2018
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分类信息：

一级分类：Electrical Engineering and Systems Science        电气工程与系统科学
二级分类：Image and Video Processing        图像和视频处理
分类描述：Theory, algorithms, and architectures for the formation, capture, processing, communication, analysis, and display of images, video, and multidimensional signals in a wide variety of applications. Topics of interest include: mathematical, statistical, and perceptual image and video modeling and representation; linear and nonlinear filtering, de-blurring, enhancement, restoration, and reconstruction from degraded, low-resolution or tomographic data; lossless and lossy compression and coding; segmentation, alignment, and recognition; image rendering, visualization, and printing; computational imaging, including ultrasound, tomographic and magnetic resonance imaging; and image and video analysis, synthesis, storage, search and retrieval.
用于图像、视频和多维信号的形成、捕获、处理、通信、分析和显示的理论、算法和体系结构。感兴趣的主题包括：数学，统计，和感知图像和视频建模和表示；线性和非线性滤波、去模糊、增强、恢复和重建退化、低分辨率或层析数据；无损和有损压缩编码；分割、对齐和识别；图像渲染、可视化和打印；计算成像，包括超声、断层和磁共振成像；以及图像和视频的分析、合成、存储、搜索和检索。
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一级分类：Physics        物理学
二级分类：Biological Physics        生物物理学
分类描述：Molecular biophysics, cellular biophysics, neurological biophysics, membrane biophysics, single-molecule biophysics, ecological biophysics, quantum phenomena in biological systems (quantum biophysics), theoretical biophysics, molecular dynamics/modeling and simulation, game theory, biomechanics, bioinformatics, microorganisms, virology, evolution, biophysical methods.
分子生物物理、细胞生物物理、神经生物物理、膜生物物理、单分子生物物理、生态生物物理、生物系统中的量子现象（量子生物物理）、理论生物物理、分子动力学/建模与模拟、博弈论、生物力学、生物信息学、微生物、病毒学、进化论、生物物理方法。
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一级分类：Physics        物理学
二级分类：Optics        光学
分类描述：Adaptive optics. Astronomical optics. Atmospheric optics. Biomedical optics. Cardinal points. Collimation. Doppler effect. Fiber optics. Fourier optics. Geometrical optics (Gradient index optics. Holography. Infrared optics. Integrated optics. Laser applications. Laser optical systems. Lasers. Light amplification. Light diffraction. Luminescence. Microoptics. Nano optics. Ocean optics. Optical computing. Optical devices. Optical imaging. Optical materials. Optical metrology. Optical microscopy. Optical properties. Optical signal processing. Optical testing techniques. Optical wave propagation. Paraxial optics. Photoabsorption. Photoexcitations. Physical optics. Physiological optics. Quantum optics. Segmented optics. Spectra. Statistical optics. Surface optics. Ultrafast optics. Wave optics. X-ray optics.
自适应光学。天文光学。大气光学。生物医学光学。基本点。准直。多普勒效应。纤维光学。傅里叶光学。几何光学（梯度折射率光学、全息术、红外光学、集成光学、激光应用、激光光学系统、激光、光放大、光衍射、发光、微光学、纳米光学、海洋光学、光学计算、光学器件、光学成像、光学材料、光学计量学、光学显微镜、光学特性、光学信号处理、光学测试技术、光波传播、傍轴光学、光吸收、光激发、物理光学、生理光学、量子光学、分段光学、光谱、统计光学、表面光学、超快光学、波动光学、X射线光学。
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英文摘要：
  We demonstrate a motion-free intensity diffraction tomography technique that enables direct inversion of 3D phase and absorption from intensity-only measurements for weakly scattering samples. We derive a novel linear forward model, featuring slice-wise phase and absorption transfer functions using angled illumination. This new framework facilitates flexible and efficient data acquisition, enabling arbitrary sampling of the illumination angles. The reconstruction algorithm performs 3D synthetic aperture using a robust, computation and memory efficient slice-wise deconvolution to achieve resolution up to the incoherent limit. We demonstrate our technique with thick biological samples having both sparse 3D structures and dense cell clusters. We further investigate the limitation of our technique when imaging strongly scattering samples. Imaging performance and the influence of multiple scattering is evaluated using a 3D sample consisting of stacked phase and absorption resolution targets. This computational microscopy system is directly built on a standard commercial microscope with a simple LED array source add-on, and promises broad applications by leveraging the ubiquitous microscopy platforms with minimal hardware modifications.
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PDF链接：
https://arxiv.org/pdf/1801.09773

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关键词：显微镜 Applications Construction Mathematical Presentation slice 传递函数 wise 散射 tomography