证明二氧化氯是一种大小选择性的抗菌剂 助剂和高纯ClO2可作为局部防腐剂

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摘要翻译：
背景/目的ClO2，即所谓的“理想杀生剂”，也可以用作防腐剂，如果人们了解为什么该溶液快速杀死微生物不会对人类或动物造成任何伤害的话。我们的目的是从理论和实验两方面研究它的反应扩散机理，寻找这种选择性的来源。方法测定ClO2在蛋白质膜中的渗透率，测定ClO2在蛋白质膜中的反应和扩散所引起的转运延迟。为了计算ClO2穿透深度和估计细菌杀灭时间，导出了反应扩散方程的近似解。此外，作为初步试验，三名感染伤口的患者用300 ppm高纯度ClO2溶液治疗，并记录了愈合过程。结果反应扩散模型的速率定律预测，杀灭时间与物体的特征尺寸（如直径）的平方成正比，因此，小的杀灭速度极快。例如，在300ppm的ClO2溶液中，对细菌的杀灭时间约为毫秒。因此，几分钟的接触时间（由于ClO2的挥发性）足以杀死所有细菌，但足够短，可以将ClO2安全地渗透到活组织中低于0.1毫米，将细胞毒性效应降至最低。伤口成功愈合的照片证实了这些考虑。本文还讨论了ClO2作为防腐剂的各种性能。最重要的是，细菌不能对ClO2产生抗性，因为它与生物硫醇反应，而硫醇在所有活的有机体中都起着至关重要的作用。结论ClO2在人和细菌之间的选择性不是基于它们的生物化学性质不同，而是基于它们的大小不同。初步的临床结果鼓励了对这种有前途的局部防腐剂的进一步研究。
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英文标题：
《Demonstrating that chlorine dioxide is a size-selective antimicrobial
  agent and high purity ClO2 can be used as a local antiseptic》
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作者：
Zolt\'an Noszticzius, Maria Wittmann, Krist\'of K\'aly-Kullai,
  Zolt\'an Beregv\'ari, Istv\'an Kiss, L\'aszl\'o Rosivall, J\'anos Szegedi
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最新提交年份：
2013
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分类信息：

一级分类：Quantitative Biology        数量生物学
二级分类：Other Quantitative Biology        其他定量生物学
分类描述：Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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英文摘要：
  Background / Aims ClO2, the so-called "ideal biocide", could also be applied as an antiseptic if it was understood why the solution's rapid killing of microbes does not cause any harm to humans or to animals. Our aim was to study both theoretically and experimentally its reaction-diffusion mechanism to find the source of that selectivity. Methods ClO2 permeation measurements through protein membranes were performed and the time delay of ClO2 transport due to reaction and diffusion was determined. To calculate ClO2 penetration depths and estimate bacterial killing times, approximate solutions of the reaction-diffusion equation were derived. Additionally, as a preliminary test, three patients with infected wounds were treated with a 300 ppm high purity ClO2 solution and the healing process was documented. Results The rate law of the reaction-diffusion model predicts that the killing time is proportional to the square of the characteristic size (e.g. diameter) of a body, thus, small ones will be killed extremely fast. For example, the killing time for a bacterium is on the order of milliseconds in a 300 ppm ClO2 solution. Thus, the few minutes of contact time (owing to the volatility of ClO2) is quite enough to kill all bacteria, but short enough to keep ClO2 penetration into the living tissues safely below 0.1 mm, minimizing cytotoxic effects. Pictures of successful wound healings confirm these considerations. Various properties of ClO2, advantageous for an antiseptic, are also discussed. Most importantly, bacteria are not able to develop resistance against ClO2 as it reacts with biological thiols which play a vital role in all living organisms. Conclusion Selectivity of ClO2 between humans and bacteria is based not on their different biochemistry, but on their different size. Preliminary clinical results encourage further research with this promising local antiseptic.
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PDF链接：
https://arxiv.org/pdf/1304.5163

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关键词：二氧化氯 选择性 CLO 防腐剂 Quantitative 细菌 bacteria 目的 反应 size