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摘要翻译：
包括老年斑和动脉粥样硬化斑块在内的衰老变化以不均匀和加速的方式发展。为了更好地理解这一现象，本文从误修积累理论中提出的误修机制来分析衰老过程中的一些变化。I.误修复是机体在严重损伤情况下为生存而采取的一种修复策略；然而，错误的修复会改变组织、细胞或分子的结构，这些都是生物体的亚结构。II.子结构的错误修复也会改变该子结构与其相邻子结构的空间关系。因此，错误的修复导致这些子结构的损伤敏感性增加和修复效率降低。因此，在发生了旧的误修的子结构及其相邻子结构上有发生误修的趋势。作为回报，新的错误修复将再次增加这些子结构和周围子结构的损伤敏感性。在这种恶性循环中，这些子结构的失修频率增加，每次失修后受影响的子结构范围扩大。因此，错误修复的积累是集中和自我加速的。三。修复不良的聚集导致组织中“斑点”或“斑块”的形成和生长。斑点的生长是自加速的，老斑点比新斑点生长得快。新斑点倾向于靠近旧斑点发展，导致斑点分布不均匀。总之，老化变化的不均匀发展是错误修复自我加速和集中积累的结果；而衰老的过程是自我加速的。
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英文标题：
《Development of aging changes: self-accelerating and inhomogeneous》
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作者：
Jicun Wang-Michelitsch, Thomas Michelitsch (DALEMBERT)
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最新提交年份：
2018
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分类信息：
一级分类：Quantitative Biology 数量生物学
二级分类：Other Quantitative Biology 其他定量生物学
分类描述：Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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英文摘要：
Aging changes including age spots and atherosclerotic plaques develop in an inhomogeneous and accelerated manner. For understanding this phenomenon, some aging changes are analyzed by Misrepair mechanism, a mechanism proposed in Misrepair-accumulation theory. I. Misrepair is a strategy of repair for survival of an organism in situations of severe injuries; however a Misrepair alters the structure of a tissue, a cell or a molecule, which are the sub-structures of an organism. II. Misrepair of a sub-structure also alters the spatial relationship of this sub-structure with its neighbor sub-structures. Thus a Misrepair leads to increased damage-sensitivity and reduced repair-efficiency of these sub-structures. As a result, Misrepairs have a tendency to occur to the sub-structure and its neighbor sub-structures where an old Misrepair has taken place. In return, new Misrepairs will increase again the damage-sensitivity of these sub-structures and the surrounding sub-structures. By such a vicious circle, the frequency of Misrepairs to these sub-structures is increased and the range of affected sub-structures is enlarged after each time of Misrepair. Thus, accumulation of Misrepairs is focalized and self-accelerating. III. Focalized accumulation of Misrepairs leads to formation and growing of a "spot" or "plaque" in a tissue. Growing of a spot is self-accelerating, and old spots grow faster than new ones. New spots tend to develop close to old ones, resulting in an inhomogeneous distribution of spots. In conclusion, the inhomogeneous development of aging changes is a result of self-accelerated and focalized accumulation of Misrepairs; and the process of aging is self-accelerating.
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PDF链接：
https://arxiv.org/pdf/1503.08076
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