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摘要翻译：
全球范围内的新冠肺炎疫情极大地加强了对冠状病毒相关分子机制的研究。只有通过详细的比较研究，才能在更广泛的进化水平上理解冠状病毒的起源以及冠状病毒感染在人与人、动物与人和人与动物之间传播的风险。本文研究了7种已知致病性人冠状病毒SARS-CoV、新型冠状病毒、MERS-CoV、HCoV-OC43、HCoV-HKU1、HCoV-229E和HCoV-NL63基因组中的核糖核酸衣壳组装包装信号(RNAPS)，并与相关动物冠状病毒SARS-Bat-CoV、MERS-Camel-CoV、MHV、Bat-CoV MOP1、TGEV和骆驼α冠状病毒基因组中的RNAPS进行了比较。冠状病毒基因组中的RNAPS是由于基因组RNA与螺旋状核衣壳中的N蛋白之间弱特异性相互作用而进化出来的。结合过渡基因组图谱和Jaccard相关系数，我们可以直接根据分布在基因组上的潜在模体进行分析。在所有冠状病毒中，RNAPS在基因组上呈准周期性分布，长于SARS-CoV和短于SARS-CoV的基因组的周期分别为54nt、57nt和51nt。与实验验证的MERS-CoV、MHV和TGEV封装信号的比较表明，特定模体的分布与封装信号有很强的相关性。我们还发现，许多基序在性状和基因组上的定位上都高度保守，这使得它们成为有希望的治疗目标。包埋机制也会影响重组和共感染。
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英文标题：
《Evolving ribonucleocapsid assembly/packaging signals in the genomes of
the human and animal coronaviruses: targeting, transmission and evolution》
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作者：
Vladimir R. Chechetkin and Vasily V. Lobzin
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最新提交年份：
2021
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分类信息：
一级分类：Quantitative Biology 数量生物学
二级分类：Other Quantitative Biology 其他定量生物学
分类描述：Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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英文摘要：
A world-wide COVID-19 pandemic intensified strongly the studies of molecular mechanisms related to the coronaviruses. The origin of coronaviruses and the risks of human-to-human, animal-to-human, and human-to-animal transmission of coronaviral infections can be understood only on a broader evolutionary level by detailed comparative studies. In this paper, we studied ribonucleocapsid assembly-packaging signals (RNAPS) in the genomes of all seven known pathogenic human coronaviruses, SARS-CoV, SARS-CoV-2, MERS-CoV, HCoV-OC43, HCoV-HKU1, HCoV-229E, and HCoV-NL63 and compared them with RNAPS in the genomes of the related animal coronaviruses including SARS-Bat-CoV, MERS-Camel-CoV, MHV, Bat-CoV MOP1, TGEV, and one of camel alphacoronaviruses. RNAPS in the genomes of coronaviruses were evolved due to weakly specific interactions between genomic RNA and N proteins in helical nucleocapsids. Combining transitional genome mapping and Jaccard correlation coefficients allows us to perform the analysis directly in terms of underlying motifs distributed over the genome. In all coronaviruses RNAPS were distributed quasi-periodically over the genome with the period about 54 nt biased to 57 nt and to 51 nt for the genomes longer and shorter than that of SARS-CoV, respectively. The comparison with the experimentally verified packaging signals for MERS-CoV, MHV, and TGEV proved that the distribution of particular motifs is strongly correlated with the packaging signals. We also found that many motifs were highly conserved in both characters and positioning on the genomes throughout the lineages that make them promising therapeutic targets. The mechanisms of encapsidation can affect the recombination and co-infection as well.
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PDF链接：
https://arxiv.org/pdf/2106.07005
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