发帖
雷达卡
摘要翻译：
感觉接触模型允许在雄性小鼠中形成由反复激动相互作用产生的不同精神病理状态（焦虑抑郁、癫痫、社交退缩、病理性攻击、超敏反应、认知障碍、快感缺乏、酒精中毒等），并研究任何药物的治疗和预防特性以及在模拟临床条件下的有效性。这种方法有助于更好地理解药物在个体疾病发展的不同阶段的作用。提示这种药理学方法可用于不同类型的新型精神药物的筛选。
---
英文标题：
《New method for the study of psychotropic drug effects under simulated
clinical conditions》
---
作者：
N. N. Kudryavtseva, D. F. Avgustinovich, N. P. Bondar, M. V.
Tenditnik, I. L. Kovalenko, L. A. Koryakina
---
最新提交年份：
2008
---
分类信息：
一级分类：Quantitative Biology 数量生物学
二级分类：Other Quantitative Biology 其他定量生物学
分类描述：Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
--
一级分类：Quantitative Biology 数量生物学
二级分类：Quantitative Methods 定量方法
分类描述：All experimental, numerical, statistical and mathematical contributions of value to biology
对生物学价值的所有实验、数值、统计和数学贡献
--
---
英文摘要：
The sensory contact model allows forming different psychopathological states (anxious depression, catalepsy, social withdrawal, pathological aggression, hypersensitivity, cognition disturbances, anhedonia, alcoholism etc.) produced by repeated agonistic interactions in male mice and investigating the therapeutic and preventive properties of any drug as well as its efficiency under simulated clinical conditions. This approach can be useful for a better understanding of the drugs' action in different stages of disease development in individuals. It is suggested that this pharmacological approach may be applied for the screening of different novel psychotropic drugs.
---
PDF链接：
https://arxiv.org/pdf/0707.3671
京公网安备 11010802022788号
