摘要翻译:
核孔复合物(NPCs)是一种非常有选择性的过滤器,它监控着细胞质和核质之间的运输。对于NPC的插头,已经提出了两种模型。它们是(i)它是可逆的水凝胶或(ii)它是聚合物刷。我们提出了一个介观模型的蛋白质通过塞运输,这是足够普遍的涵盖两者。蛋白质拉伸塞子并造成局部变形。这样创建的气泡(prtoein+变形)在插头中执行随机游动。我们发现,为了使凝胶更快地松弛,气泡的扩散更大。此外,在使用合适的电刷参数时,我们发现扩散系数要低得多。因此,凝胶模型似乎更可能解释塞子的工作。
---
英文标题:
《Diffusion of Macromolecules across the Nuclear Pore Complex》
---
作者:
Rajarshi Chakrabarti, Ananya Debnath and K. L. Sebastian
---
最新提交年份:
2007
---
分类信息:
一级分类:Physics 物理学
二级分类:Soft Condensed Matter 软凝聚态物质
分类描述:Membranes, polymers, liquid crystals, glasses, colloids, granular matter
膜,聚合物,液晶,玻璃,胶体,颗粒物质
--
一级分类:Physics 物理学
二级分类:Statistical Mechanics 统计力学
分类描述:Phase transitions, thermodynamics, field theory, non-equilibrium phenomena, renormalization group and scaling, integrable models, turbulence
相变,热力学,场论,非平衡现象,重整化群和标度,可积模型,湍流
--
一级分类:Physics 物理学
二级分类:Biological Physics 生物物理学
分类描述:Molecular biophysics, cellular biophysics, neurological biophysics, membrane biophysics, single-molecule biophysics, ecological biophysics, quantum phenomena in biological systems (quantum biophysics), theoretical biophysics, molecular dynamics/modeling and simulation, game theory, biomechanics, bioinformatics, microorganisms, virology, evolution, biophysical methods.
分子生物物理、细胞生物物理、神经生物物理、膜生物物理、单分子生物物理、生态生物物理、生物系统中的量子现象(量子生物物理)、理论生物物理、分子动力学/建模与模拟、博弈论、生物力学、生物信息学、微生物、病毒学、进化论、生物物理方法。
--
一级分类:Quantitative Biology 数量生物学
二级分类:Cell Behavior 细胞行为
分类描述:Cell-cell signaling and interaction; morphogenesis and development; apoptosis; bacterial conjugation; viral-host interaction; immunology
细胞-细胞信号传导及相互作用;形态发生和发育;细胞凋亡;细菌接合;病毒-宿主相互作用;免疫学
--
---
英文摘要:
Nuclear pore complexes (NPCs) are very selective filters that monitor the transport between the cytoplasm and the nucleoplasm. Two models have been suggested for the plug of the NPC. They are (i) it is a reversible hydrogel or (ii) it is a polymer brush. We propose a mesoscopic model for the transport of a protein through the plug, that is general enough to cover both. The protein stretches the plug and creates a local deformation. The bubble so created (prtoein+deformation) executes random walk in the plug. We find that for faster relaxation of the gel, the diffusion of the bubble is greater. Further, on using parameters appropriate for the brush, we find that the diffusion coefficient is much lower. Hence the gel model seems to be more likely explanation for the workings of the plug.
---
PDF链接:
https://arxiv.org/pdf/706.3758