皮肤健康中的内源性和微生物挥发性有机化合物 和疾病

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摘要翻译：
人体皮肤是一个代谢活跃的区域，角质层分泌丰富多样的生物标志物。皮肤是挥发性有机化合物（VOCs）的持续来源，来源于皮肤腺体和常驻微生物群。皮肤VOCs包含了细胞活动的足迹，因此提供了对皮肤生理复杂过程的独特见解。本文综述了皮肤挥发性有机化合物标记物与皮肤生理学相关的研究，其中皮肤固有和微生物代谢过程的变化导致了独特的挥发性特征。研究了与皮肤扰动和皮肤癌相关的挥发性生物标志物的新证据。微生物来源的VOCs也被研究作为前瞻性的诊断标志，它们可能塑造局部皮肤微生物群的组成，从而影响皮肤健康。最后，对基于皮肤VOC的研究和诊断所面临的挑战和机遇进行了简要的展望。
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英文标题：
《Endogenous and microbial volatile organic compounds in cutaneous health
  and disease》
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作者：
Emer Duffy, Aoife Morrin
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最新提交年份：
2020
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分类信息：

一级分类：Quantitative Biology        数量生物学
二级分类：Other Quantitative Biology        其他定量生物学
分类描述：Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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英文摘要：
  Human skin is a region of high metabolic activity where a rich variety of biomarkers are secreted from the stratum corneum. The skin is a constant source of volatile organic compounds (VOCs) derived from skin glands and resident microbiota. Skin VOCs contain the footprints of cellular activities and thus offer unique insights into the intricate processes of cutaneous physiology. This review examines the growing body of research on skin VOC markers as they relate to skin physiology, whereby variations in skin-intrinsic and microbial metabolic processes give rise to unique volatile profiles. Emerging evidence for volatile biomarkers linked to skin perturbations and skin cancer are examined. Microbial-derived VOCs are also investigated as prospective diagnostic markers, and their potential to shape the composition of the local skin microbiota, and consequently cutaneous health, is considered. Finally, a brief outlook on emerging analytical challenges and opportunities for skin VOC-based research and diagnostics is presented.
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PDF链接：
https://arxiv.org/pdf/2007.15507

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关键词：皮肤健康 微生物 内源性 化合物 Quantitative cutaneous 皮肤 VOCs 标志物 研究