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摘要翻译：
在许多细胞内过程中，微管的长度分布是由解聚运动蛋白控制的。实验表明，解聚剂与微管表面非特异性结合后，通过扩散或定向行走的方式转移到微管尖端，然后在微管尖端聚集后将微管解聚。我们建立了一个定量模型来研究这类通用运动蛋白的解聚作用及其对微管长度分布的可能影响。结果表明，当溶液中运动蛋白浓度超过某一临界值时，其长度分布一般为单峰非单调分布，达到稳定状态。然而，对于高进程电机和大电机密度，这种分布实际上变成指数衰减。我们的发现表明，这些运动蛋白可能被细胞选择性地使用，以确保对MT长度的精确控制。该模型还用于分析运动诱导解聚的实验观察。
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英文标题：
《Length control of microtubules by depolymerizing motor proteins》
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作者：
Bindu S. Govindan, Manoj Gopalakrishnan (HRI, Allahabad) and Debashish
Chowdhury (IIT Kanpur)
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最新提交年份：
2008
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分类信息：
一级分类：Physics 物理学
二级分类：Biological Physics 生物物理学
分类描述：Molecular biophysics, cellular biophysics, neurological biophysics, membrane biophysics, single-molecule biophysics, ecological biophysics, quantum phenomena in biological systems (quantum biophysics), theoretical biophysics, molecular dynamics/modeling and simulation, game theory, biomechanics, bioinformatics, microorganisms, virology, evolution, biophysical methods.
分子生物物理、细胞生物物理、神经生物物理、膜生物物理、单分子生物物理、生态生物物理、生物系统中的量子现象（量子生物物理）、理论生物物理、分子动力学/建模与模拟、博弈论、生物力学、生物信息学、微生物、病毒学、进化论、生物物理方法。
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一级分类：Physics 物理学
二级分类：Statistical Mechanics 统计力学
分类描述：Phase transitions, thermodynamics, field theory, non-equilibrium phenomena, renormalization group and scaling, integrable models, turbulence
相变，热力学，场论，非平衡现象，重整化群和标度，可积模型，湍流
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一级分类：Quantitative Biology 数量生物学
二级分类：Subcellular Processes 亚细胞过程
分类描述：Assembly and control of subcellular structures (channels, organelles, cytoskeletons, capsules, etc.); molecular motors, transport, subcellular localization; mitosis and meiosis
亚细胞结构（通道、细胞器、细胞骨架、囊膜等）的组装和控制；分子马达；转运；亚细胞定位；有丝分裂和减数分裂
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英文摘要：
In many intracellular processes, the length distribution of microtubules is controlled by depolymerizing motor proteins. Experiments have shown that, following non-specific binding to the surface of a microtubule, depolymerizers are transported to the microtubule tip(s) by diffusion or directed walk and, then, depolymerize the microtubule from the tip(s) after accumulating there. We develop a quantitative model to study the depolymerizing action of such a generic motor protein, and its possible effects on the length distribution of microtubules. We show that, when the motor protein concentration in solution exceeds a critical value, a steady state is reached where the length distribution is, in general, non-monotonic with a single peak. However, for highly processive motors and large motor densities, this distribution effectively becomes an exponential decay. Our findings suggest that such motor proteins may be selectively used by the cell to ensure precise control of MT lengths. The model is also used to analyze experimental observations of motor-induced depolymerization.
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PDF链接：
https://arxiv.org/pdf/709.3675
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